Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity
K Sliepen, G Ozorowski, JA Burger, T van Montfort… - Retrovirology, 2015 - Springer
Background Presenting vaccine antigens in particulate form can improve their
immunogenicity by enhancing B cell activation. Findings We describe ferritin-based protein …
immunogenicity by enhancing B cell activation. Findings We describe ferritin-based protein …
Two-component ferritin nanoparticles for multimerization of diverse trimeric antigens
Antigen multimerization on a nanoparticle can result in improved neutralizing antibody
responses. A platform that has been successfully used for displaying antigens from a …
responses. A platform that has been successfully used for displaying antigens from a …
Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles
The HIV-1 envelope glycoprotein trimer is poorly immunogenic because it is covered by a
dense glycan shield. As a result, recombinant Env glycoproteins generally elicit inadequate …
dense glycan shield. As a result, recombinant Env glycoproteins generally elicit inadequate …
mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice
The success of nucleoside-modified mRNAs in lipid nanoparticles (mRNA-LNP) as COVID-
19 vaccines heralded a new era of vaccine development. For HIV-1, multivalent envelope …
19 vaccines heralded a new era of vaccine development. For HIV-1, multivalent envelope …
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
The development of native-like HIV-1 envelope (Env) trimer antigens has enabled the
induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 …
induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 …
Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles
L He, N De Val, CD Morris, N Vora, TC Thinnes… - Nature …, 2016 - nature.com
Structures of BG505 SOSIP. 664 trimer in complex with broadly neutralizing antibodies
(bNAbs) have revealed the critical role of trimeric context for immune recognition of HIV-1 …
(bNAbs) have revealed the critical role of trimeric context for immune recognition of HIV-1 …
Antigen-and scaffold-specific antibody responses to protein nanoparticle immunogens
Protein nanoparticle scaffolds are increasingly used in next-generation vaccine designs,
and several have established records of clinical safety and efficacy. Yet the rules for how …
and several have established records of clinical safety and efficacy. Yet the rules for how …
Nanoparticle vaccines for inducing HIV-1 neutralizing antibodies
M Brinkkemper, K Sliepen - Vaccines, 2019 - mdpi.com
The enormous sequence diversity between human immunodeficiency virus type 1 (HIV-1)
strains poses a major roadblock for generating a broadly protective vaccine. Many …
strains poses a major roadblock for generating a broadly protective vaccine. Many …
Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens
A Antanasijevic, G Ueda, PJM Brouwer, J Copps… - PLoS …, 2020 - journals.plos.org
Two-component, self-assembling nanoparticles represent a versatile platform for multivalent
presentation of viral antigens. Computational design of protein nanoparticles with differing …
presentation of viral antigens. Computational design of protein nanoparticles with differing …
High-density array of well-ordered HIV-1 spikes on synthetic liposomal nanoparticles efficiently activate B cells
J Ingale, A Stano, J Guenaga, SK Sharma, D Nemazee… - Cell reports, 2016 - cell.com
A major step toward an HIV-1 vaccine is an immunogen capable of inducing neutralizing
antibodies. Envelope glycoprotein (Env) mimetics, such as the NFL and SOSIP designs …
antibodies. Envelope glycoprotein (Env) mimetics, such as the NFL and SOSIP designs …