Glucocorticosteroids: current and future directions

PJ Barnes - British journal of pharmacology, 2011 - Wiley Online Library
Glucocorticoids are the most effective anti‐inflammatory therapy for asthma yet are relatively
ineffective in chronic obstructive pulmonary disease. Glucocorticoids suppress inflammation …

How corticosteroids control inflammation: quintiles prize lecture 2005

PJ Barnes - British journal of pharmacology, 2006 - Wiley Online Library
Corticosteroids are the most effective anti‐inflammatory therapy for many chronic
inflammatory diseases, such as asthma but are relatively ineffective in other diseases such …

Mechanisms and resistance in glucocorticoid control of inflammation

PJ Barnes - The Journal of steroid biochemistry and molecular …, 2010 - Elsevier
Glucocorticoids are the most effective anti-inflammatory therapy for many chronic
inflammatory and immune diseases, such as asthma, but are relatively ineffective in other …

Corticosteroids: the drugs to beat

PJ Barnes - European journal of pharmacology, 2006 - Elsevier
Corticosteroids are the most effective anti-inflammatory therapy for asthma and other chronic
inflammatory and immune diseases. Recently new insights have been gained into the …

Glucocorticoids: mechanisms of action and anti‐inflammatory potential in asthma

VHJ Van Der Velden - Mediators of inflammation, 1998 - Wiley Online Library
Glucocorticoids are potent inhibitors of inflammatory processes and are widely used in the
treatment of asthma. The anti‐inflammatory effects are mediated either by direct binding of …

Molecular mechanisms and cellular effects of glucocorticosteroids

PJ Barnes - Immunology and Allergy Clinics, 2005 - immunology.theclinics.com
Glucocorticosteroids (GCSs) are widely used to treat various inflammatory and immune
diseases. The most common use of GCSs today is in the treatment of asthma and other …

Glucocorticoid-regulated transcription factors

IM Adcock - Pulmonary pharmacology & therapeutics, 2001 - Elsevier
Glucocorticoids are the most effective antiinflammatory drugs used in the treatment of
asthma. They act by binding to a specific receptor (GR) that, upon activation, translocates to …

[HTML][HTML] Why do some asthma patients respond poorly to glucocorticoid therapy?

I Henderson, E Caiazzo, C McSharry, TJ Guzik… - Pharmacological …, 2020 - Elsevier
Glucocorticosteroids are the first-line therapy for controlling airway inflammation in asthma.
They bind intracellular glucocorticoid receptors to trigger increased expression of anti …

Anti-inflammatory actions of glucocorticoids: molecular mechanisms

PJ Barnes - Clinical science, 1998 - portlandpress.com
1. Glucocorticoids are widely used for the suppression of inflammation in chronic
inflammatory diseases such as asthma, rheumatoid arthritis, inflammatory bowel disease …

Update on glucocorticoid action and resistance

K Ito, KF Chung, IM Adcock - Journal of Allergy and Clinical Immunology, 2006 - Elsevier
Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic …