Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective

D Albuquerque, E Stice, R Rodríguez-López… - Molecular genetics and …, 2015 - Springer
It is well-known that obesity is a complex multifactorial and heterogeneous condition with an
important genetic component. Recently, major advances in obesity research emerged …

Recent advances in obesity: genetics and beyond

WW Cheung, P Mao - International Scholarly Research Notices, 2012 - Wiley Online Library
The prevalence of obesity, which is a heritable trait that arises from the interactions of
multiple genes and lifestyle factors, continues to increase worldwide, causing serious health …

The genetics of human obesity

CG Bell, AJ Walley, P Froguel - Nature reviews genetics, 2005 - nature.com
Obesity is an important cause of morbidity and mortality in developed countries, and is also
becoming increasingly prevalent in the developing world. Although environmental factors …

Genetics and epigenetics in obesity

K Rohde, M Keller, L la Cour Poulsen, M Blüher… - Metabolism, 2019 - Elsevier
Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …

[HTML][HTML] Molecular genetics of human obesity: A comprehensive review

RK Singh, P Kumar, K Mahalingam - Comptes rendus biologies, 2017 - Elsevier
Obesity and its related health complications is a major problem worldwide. Hypothalamus
and their signalling molecules play a critical role in the intervening and coordination with …

Molecular basis of obesity: current status and future prospects

H Choquet, D Meyre - Current genomics, 2011 - ingentaconnect.com
Obesity is a global health problem that is gradually affecting each continent of the world.
Obesity is a heterogeneous disorder, and the biological causes of obesity are complex. The …

Genetic factors for human obesity

S Ichihara, Y Yamada - Cellular and molecular life sciences, 2008 - Springer
Obesity is a multifactorial and heterogeneous condition that results from alterations of
various genes, each having a partial and additive effect. The inheritance pattern of obesity is …

Genetics of obesity: what have we learned?

H Choquet, D Meyre - Current genomics, 2011 - ingentaconnect.com
Candidate gene and genome-wide association studies have led to the discovery of nine loci
involved in Mendelian forms of obesity and 58 loci contributing to polygenic obesity. These …

The genetics of human obesity

Q Xia, SFA Grant - Annals of the New York Academy of …, 2013 - Wiley Online Library
It has long been known that there is a genetic component to obesity, and that characterizing
this underlying factor would likely offer the possibility of better intervention in the future …

Impact of genetic variations and epigenetic mechanisms on the risk of obesity

M Chiurazzi, M Cozzolino, RC Orsini… - International Journal of …, 2020 - mdpi.com
Rare genetic obesity disorders are characterized by mutations of genes strongly involved in
the central or peripheral regulation of energy balance. These mutations are effective in …