[HTML][HTML] The mitophagy pathway and its implications in human diseases

S Wang, H Long, L Hou, B Feng, Z Ma, Y Wu… - Signal transduction and …, 2023 - nature.com
Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

K Palikaras, E Lionaki, N Tavernarakis - Nature cell biology, 2018 - nature.com
Mitophagy is an evolutionarily conserved cellular process to remove dysfunctional or
superfluous mitochondria, thus fine-tuning mitochondrial number and preserving energy …

Mitophagy pathways in health and disease

SA Killackey, DJ Philpott, SE Girardin - Journal of Cell Biology, 2020 - rupress.org
Mitophagy is an evolutionarily conserved process involving the autophagic targeting and
clearance of mitochondria destined for removal. Recent insights into the complex nature of …

[HTML][HTML] Emerging role of mitophagy in human diseases and physiology

JH Um, J Yun - BMB reports, 2017 - ncbi.nlm.nih.gov
Mitophagy is a process of selective removal of damaged or unnecessary mitochondria using
autophagic machinery. Mitophagy plays an essential role in maintaining mitochondrial …

Mitophagy mechanisms and role in human diseases

M Redmann, M Dodson, M Boyer-Guittaut… - The international journal …, 2014 - Elsevier
Mitophagy is a process of mitochondrial turnover through lysosomal mediated autophagy
activities. This review will highlight recent studies that have identified mediators of …

Evolving and expanding the roles of mitophagy as a homeostatic and pathogenic process

ÅB Gustafsson, GW Dorn - Physiological reviews, 2019 - journals.physiology.org
The central functions fulfilled by mitochondria as both energy generators essential for tissue
homeostasis and gateways to programmed apoptotic and necrotic cell death mandate tight …

Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases

X Li, L Huang, J Lan, X Feng, P Li, L Wu… - Pharmacological …, 2021 - Elsevier
Neurodegenerative diseases are the most common diseases of the nervous system in
elderly people, which are currently incurable and cause great burden to families and …

The role of mitophagy in regulating cell death

S Li, J Zhang, C Liu, Q Wang, J Yan… - Oxidative Medicine …, 2021 - Wiley Online Library
Mitochondria are multifaceted organelles that serve to power critical cellular functions,
including act as power generators of the cell, buffer cytosolic calcium overload, production of …

[HTML][HTML] Mitophagy regulates neurodegenerative diseases

X Cen, M Zhang, M Zhou, L Ye, H Xia - Cells, 2021 - mdpi.com
Mitochondria play an essential role in supplying energy for the health and survival of
neurons. Mitophagy is a metabolic process that removes dysfunctional or redundant …

[HTML][HTML] Role and mechanisms of mitophagy in liver diseases

X Ma, T McKeen, J Zhang, WX Ding - Cells, 2020 - mdpi.com
The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular
redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both …