Reversal of ApoE4-driven brain pathology by vascular endothelial growth factor treatment
S Salomon-Zimri, MJ Glat, Y Barhum… - Journal of …, 2016 - content.iospress.com
Abstract Apolipoprotein E4 (ApoE4), the most prevalent genetic risk factor for Alzheimer's
disease (AD), is associated with increased neurodegeneration and vascular impairments …
disease (AD), is associated with increased neurodegeneration and vascular impairments …
Epidermal growth factor treatment of female mice that express APOE4 at an age of advanced pathology mitigates behavioral and cerebrovascular dysfunction
S Zaldua, FC Damen, R Pisharody, R Thomas, KD Fan… - Heliyon, 2020 - cell.com
APOE4 is a major genetic risk factor for Alzheimer's disease and high amyloid-β (Aβ) levels
in the brain are a pathological hallmark of the disease. However, the contribution of specific …
in the brain are a pathological hallmark of the disease. However, the contribution of specific …
VEGF mediates ApoE4-induced neovascularization and synaptic pathology in the choroid and retina
R Antes, S Salomon-Zimri, SC Beck… - Current Alzheimer …, 2015 - ingentaconnect.com
Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for Alzheimer's disease
(AD), is associated with neuronal and vascular impairments. Recent findings suggest that …
(AD), is associated with neuronal and vascular impairments. Recent findings suggest that …
The role of MAPK's signaling in mediating ApoE4-driven pathology in vivo
Background: Alzheimer's Disease (AD) is associated with impairments in key brain Mitogen-
Activated Protein Kinase (MAPK) signaling cascades including the p38, c-Jun N-terminal …
Activated Protein Kinase (MAPK) signaling cascades including the p38, c-Jun N-terminal …
Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and cerebrovascular deficits in female mice
R Thomas, P Zuchowska, AWJ Morris… - Acta neuropathologica …, 2016 - Springer
Cerebrovascular (CV) dysfunction is emerging as a critical component of Alzheimer's
disease (AD), including altered CV coverage. Angiogenic growth factors (AGFs) are key for …
disease (AD), including altered CV coverage. Angiogenic growth factors (AGFs) are key for …
Peripheral ApoE4 leads to cerebrovascular dysfunction and aβ deposition in alzheimer's disease
R Sun, C Xie - Neuroscience Bulletin, 2023 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
cognitive dysfunction and behavioral impairment that occurs in old age and pre-old age [1] …
cognitive dysfunction and behavioral impairment that occurs in old age and pre-old age [1] …
The role of APOE in cerebrovascular dysfunction
LM Tai, R Thomas, FM Marottoli, KP Koster… - Acta …, 2016 - Springer
The ε4 allele of the apolipoprotein E gene (APOE4) is associated with cognitive decline
during aging, is the greatest genetic risk factor for Alzheimer's disease and has links to other …
during aging, is the greatest genetic risk factor for Alzheimer's disease and has links to other …
[HTML][HTML] APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease
Literature suggests vascular endothelial growth factor A (VEGFA) is protective among those
at highest risk for Alzheimer's disease (AD). Apolipoprotein E (APOE) ε4 allele carriers …
at highest risk for Alzheimer's disease (AD). Apolipoprotein E (APOE) ε4 allele carriers …
ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice
O Liraz, A Boehm-Cagan, DM Michaelson - Molecular neurodegeneration, 2013 - Springer
Background Recent findings suggest that the pathological effects of apoE4, the most
prevalent genetic risk factor for Alzheimer's disease (AD), start many years before the onset …
prevalent genetic risk factor for Alzheimer's disease (AD), start many years before the onset …
Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function
The ε4 allele of the apolipoprotein E (APOE) gene, a genetic risk factor for Alzheimer's
disease, is abundantly expressed in both the brain and periphery. Here, we present …
disease, is abundantly expressed in both the brain and periphery. Here, we present …