Detyrosinated microtubules provide mechanical resistance that can impede the motion of
contracting cardiomyocytes. However, the functional effects of microtubule detyrosination in …

INTRODUCTION Along with its well-documented role as a track for cargo transport, the
microtubule (MT) cytoskeleton is linked to diverse structural and signaling roles in the …

In striated muscle, X-ROS is the mechanotransduction pathway by which mechanical stress
transduced by the microtubule network elicits reactive oxygen species. X-ROS tunes Ca2+ …

The microtubule network of cardiac muscle cells has unique architectural and biophysical
features to accommodate the demands of the working heart. Advances in live-cell imaging …

Background Microtubules (MT) buckle and bear load during myocyte contraction, a behavior
enhanced by post-translational detyrosination. This buckling suggests a spring-like …

Microtubules are essential cytoskeletal elements found in all eukaryotic cells. The structure
and composition of microtubules regulate their function, and the dynamic remodeling of the …

Cardiomyocytes are large (∼ 40,000 µm3), rod-shaped muscle cells that provide the
working force behind each heartbeat. These highly structured cells are packed with dense …

Microtubules tune cytoskeletal stiffness, which affects cytoskeletal mechanics and
mechanotransduction of striated muscle. While recent evidence suggests that microtubules …

Background—Cardiac dysfunction in failing hearts of human patients and animal models is
associated with both microtubule densification and transverse-tubule (T-tubule) remodeling …

In the failing heart, the cardiac myocyte microtubule network is remodeled, which contributes
to cellular contractile failure and patient death. However, the origins of this deleterious …