Intestinal alkaline phosphatase: novel functions and protective effects

JP Lallès - Nutrition reviews, 2014 - academic.oup.com
Important protective roles of intestinal alkaline phosphatase (IAP)–including regulation of
intestinal surface pH, absorption of lipids, detoxification of free nucleotides and bacterial …

Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet

JP Lallès - Nutrition reviews, 2010 - academic.oup.com
The diverse nature of intestinal alkaline phosphatase (IAP) functions has remained elusive,
and it is only recently that four additional major functions of IAP have been revealed. The …

[HTML][HTML] Interplay between intestinal alkaline phosphatase, diet, gut microbes and immunity

M Estaki, D DeCoffe, DL Gibson - World Journal of …, 2014 - ncbi.nlm.nih.gov
Intestinal alkaline phosphatase (IAP) plays an essential role in intestinal homeostasis and
health through interactions with the resident microbiota, diet and the gut. IAP's role in the …

The role of intestinal alkaline phosphatase in inflammatory disorders of gastrointestinal tract

J Bilski, A Mazur-Bialy, D Wojcik… - Mediators of …, 2017 - Wiley Online Library
Over the past few years, the role of intestinal alkaline phosphatase (IAP) as a crucial
mucosal defence factor essential for maintaining gut homeostasis has been established. IAP …

Recent advances in intestinal alkaline phosphatase, inflammation, and nutrition

JP Lallès - Nutrition reviews, 2019 - academic.oup.com
In recent years, much new data on intestinal alkaline phosphatase (IAP) have been
published, and major breakthroughs have been disclosed. The aim of the present review is …

Intestinal alkaline phosphatase: a summary of its role in clinical disease

J Fawley, DM Gourlay - Journal of Surgical Research, 2016 - Elsevier
Over the past few years, there is increasing evidence implicating a novel role for Intestinal
Alkaline Phosphatase (IAP) in mitigating inflammatory mediated disorders. IAP is an …

Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates

MS Malo, O Moaven, N Muhammad… - American Journal …, 2014 - journals.physiology.org
The intestinal microbiota plays a pivotal role in maintaining human health and well-being.
Previously, we have shown that mice deficient in the brush-border enzyme intestinal alkaline …

Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase

KT Chen, MS Malo, AK Moss, S Zeller… - American Journal …, 2010 - journals.physiology.org
Intestinal alkaline phosphatase (IAP) is a small intestinal brush border enzyme that has
been shown to function as a gut mucosal defense factor, but its precise mechanism of action …

Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition

RF Goldberg, WG Austen Jr, X Zhang… - Proceedings of the …, 2008 - National Acad Sciences
Under conditions of starvation and disease, the gut barrier becomes impaired, and trophic
feeding to prevent gut mucosal atrophy has become a standard treatment of critically ill …

Alkaline phosphatase, an unconventional immune protein

BA Rader - Frontiers in immunology, 2017 - frontiersin.org
Recent years have seen an increase in the number of studies focusing on alkaline
phosphatases (APs), revealing an expanding complexity of function of these enzymes. Of …