Loss-of-function mutations in the genes encoding either neurokinin B (NKB) or its receptor,
NK3 (NK3R), result in hypogonadotropic hypogonadism, characterized by an absence of …

Humans carrying mutations in neurokinin B (NKB) or the NKB receptor fail to undergo
puberty due to decreased secretion of GnRH. Despite this pubertal delay, many of these …

Neurokinin B (NKB), encoded by Tac2 in rodents, and its receptor, NK3R, have recently
emerged as important regulators of reproduction; NKB has been proposed to stimulate …

Tachykinins play a critical role in neuroendocrine regulation of reproduction. The best
known members of the family are substance P (SP), neurokinin A and neurokinin B …

The discovery of the essential requirement for kisspeptin and subsequently neurokinin B
signalling for human reproductive function has sparked renewed interest in the …

Context: The recent report that loss-of-function mutations in either the gene encoding
neurokinin B (NKB) or its receptor (NK3R) produce gonadotropin deficiencies in humans …

GnRH neurons form the final common pathway for the central control of reproduction. GnRH
release occurs from terminals in the external layer of the median eminence (ME) for …

Growing evidence suggests the tachykinin neurokinin B (NKB) may modulate gonadotrophin
secretion and play a role in sex‐steroid feedback within the reproductive axis. NKB …

Patients bearing mutations in TAC3 and TACR3 (which encode neurokinin B and its
receptor, respectively) have sexual infantilism and infertility due to GnRH deficiency. In …

Context: The neurokinin B (NKB) receptor, encoded by TACR3, is widely expressed within
the central nervous system, including hypothalamic nuclei involved in regulating GnRH …