Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by
mediating a wide range of cellular and systemic adaptive physiological responses to …

The hypoxia-inducible factor (HIF)-1α and HIF-2α are closely related, key transcriptional
regulators of the hypoxic response, countering a low oxygen situation with the up-regulation …

The hypoxia-inducible factor α subunits 1 and 2 (HIF-1α and HIF-2α) are subjected to
oxygen-dependent asparaginyl hydroxylation, a modification that represses the carboxyl …

HIF1 (hypoxia-inducible factor 1 alpha) is considered a central oxygen-threshold sensor in
mammalian cells. In the presence of oxygen, HIF1 is marked by prolyl hydroxylases (PHDs) …

The hypoxia-inducible factor (HIF) hydroxylases regulate hypoxia sensing in animals. In
humans, they comprise three prolyl hydroxylases (PHD1–3 or EGLN1–3) and factor …

The hypoxia inducible transcription factors (HIFs) are regulated at the level of protein
stability and transcriptional activity in an oxygen‐dependent manner by prolyl and …

Oxygen (O 2) is an essential nutrient that serves as a key substrate in cellular metabolism
and bioenergetics. In a variety of physiological and pathological states, organisms …

Cell adaptation to changes in oxygen (O2) availability is controlled by two subfamilies of O2-
dependent enzymes: the hypoxia inducible factor (HIF)–prolyl and asparaginyl hydroxylases …

Metazoans rapidly respond to changes in oxygen availability by regulating gene expression.
The transcription factor hypoxia‐inducible‐factor (HIF), which controls the expression of …

Hypoxia-inducible transcription factor (HIF), an αβ dimer, is the key inducer of hypoxia-
responsive genes that operate both during normal development and pathological processes …