Butyrate and dietary soluble fiber improve neuroinflammation associated with aging in mice

SM Matt, JM Allen, MA Lawson, LJ Mailing… - Frontiers in …, 2018 - frontiersin.org
Aging results in chronic systemic inflammation that can alter neuroinflammation of the brain.
Specifically, microglia shift to a pro-inflammatory phenotype predisposing them to …

Dietary fiber modulates the release of gut bacterial products preventing cognitive decline in an Alzheimer's mouse model

D Cuervo-Zanatta, T Syeda, V Sánchez-Valle… - Cellular and molecular …, 2023 - Springer
Fiber intake is associated with a lower risk for Alzheimer´ s disease (AD) in older adults.
Intake of plant-based diets rich in soluble fiber promotes the production of short-chain fatty …

Butyrate suppresses demyelination and enhances remyelination

T Chen, D Noto, Y Hoshino, M Mizuno… - Journal of …, 2019 - Springer
Background The association of gut microbiota and diseases of the central nervous system
(CNS), including multiple sclerosis (MS), has attracted much attention. Although a previous …

[HTML][HTML] Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?

MW Bourassa, I Alim, SJ Bultman, RR Ratan - Neuroscience letters, 2016 - Elsevier
As interest in the gut microbiome has grown in recent years, attention has turned to the
impact of our diet on our brain. The benefits of a high fiber diet in the colon have been well …

Intermittent fasting protects against Alzheimer's disease in mice by altering metabolism through remodeling of the gut microbiota

RY Pan, J Zhang, J Wang, Y Wang, Z Li, Y Liao, Y Liao… - Nature Aging, 2022 - nature.com
Alzheimer's disease (AD) is the most common form of dementia without effective clinical
treatment. Here, we show that intermittent fasting (IF) improves cognitive functions and AD …

Sodium butyrate ameliorates the impairment of synaptic plasticity by inhibiting the neuroinflammation in 5XFAD mice

Y Jiang, K Li, X Li, L Xu, Z Yang - Chemico-biological interactions, 2021 - Elsevier
Current strategies for the treatment of Alzheimer's disease (AD) focus on the pathology in the
later stages of disease progression. Early microglia abnormality and β-amyloid (Aβ) …

Target intestinal microbiota to alleviate disease progression in amyotrophic lateral sclerosis

Y Zhang, S Wu, J Yi, Y Xia, D Jin, J Zhou, J Sun - Clinical therapeutics, 2017 - Elsevier
Purpose Emerging evidence has demonstrated that gut microbiome plays essential roles in
the pathogenesis of human diseases in distal organs. Amyotrophic lateral sclerosis (ALS) is …

Short-chain fatty acids (SCFAs) alone or in combination regulate select immune functions of microglia-like cells

TJ Wenzel, EJ Gates, AL Ranger, A Klegeris - Molecular and Cellular …, 2020 - Elsevier
Neuroinflammation contributes to neurodegenerative disorders, including Alzheimer's
disease (AD). Gut microbes are involved in regulating systemic inflammation. Short-chain …

Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation

R Velazquez, E Ferreira, S Knowles, C Fux… - Aging cell, 2019 - Wiley Online Library
Currently, there are no effective therapies to ameliorate the pathological progression of
Alzheimer's disease (AD). Evidence suggests that environmental factors may contribute to …

High-fat diet and aging interact to produce neuroinflammation and impair hippocampal-and amygdalar-dependent memory

SJ Spencer, H D'Angelo, A Soch, LR Watkins… - Neurobiology of …, 2017 - Elsevier
More Americans are consuming diets higher in saturated fats and refined sugars than ever
before, and based on increasing obesity rates, this is a growing trend among older adults as …