Butyrate and dietary soluble fiber improve neuroinflammation associated with aging in mice
Aging results in chronic systemic inflammation that can alter neuroinflammation of the brain.
Specifically, microglia shift to a pro-inflammatory phenotype predisposing them to …
Specifically, microglia shift to a pro-inflammatory phenotype predisposing them to …
Dietary fiber modulates the release of gut bacterial products preventing cognitive decline in an Alzheimer's mouse model
D Cuervo-Zanatta, T Syeda, V Sánchez-Valle… - Cellular and molecular …, 2023 - Springer
Fiber intake is associated with a lower risk for Alzheimer´ s disease (AD) in older adults.
Intake of plant-based diets rich in soluble fiber promotes the production of short-chain fatty …
Intake of plant-based diets rich in soluble fiber promotes the production of short-chain fatty …
Butyrate suppresses demyelination and enhances remyelination
T Chen, D Noto, Y Hoshino, M Mizuno… - Journal of …, 2019 - Springer
Background The association of gut microbiota and diseases of the central nervous system
(CNS), including multiple sclerosis (MS), has attracted much attention. Although a previous …
(CNS), including multiple sclerosis (MS), has attracted much attention. Although a previous …
[HTML][HTML] Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?
As interest in the gut microbiome has grown in recent years, attention has turned to the
impact of our diet on our brain. The benefits of a high fiber diet in the colon have been well …
impact of our diet on our brain. The benefits of a high fiber diet in the colon have been well …
Intermittent fasting protects against Alzheimer's disease in mice by altering metabolism through remodeling of the gut microbiota
RY Pan, J Zhang, J Wang, Y Wang, Z Li, Y Liao, Y Liao… - Nature Aging, 2022 - nature.com
Alzheimer's disease (AD) is the most common form of dementia without effective clinical
treatment. Here, we show that intermittent fasting (IF) improves cognitive functions and AD …
treatment. Here, we show that intermittent fasting (IF) improves cognitive functions and AD …
Sodium butyrate ameliorates the impairment of synaptic plasticity by inhibiting the neuroinflammation in 5XFAD mice
Y Jiang, K Li, X Li, L Xu, Z Yang - Chemico-biological interactions, 2021 - Elsevier
Current strategies for the treatment of Alzheimer's disease (AD) focus on the pathology in the
later stages of disease progression. Early microglia abnormality and β-amyloid (Aβ) …
later stages of disease progression. Early microglia abnormality and β-amyloid (Aβ) …
Target intestinal microbiota to alleviate disease progression in amyotrophic lateral sclerosis
Purpose Emerging evidence has demonstrated that gut microbiome plays essential roles in
the pathogenesis of human diseases in distal organs. Amyotrophic lateral sclerosis (ALS) is …
the pathogenesis of human diseases in distal organs. Amyotrophic lateral sclerosis (ALS) is …
Short-chain fatty acids (SCFAs) alone or in combination regulate select immune functions of microglia-like cells
TJ Wenzel, EJ Gates, AL Ranger, A Klegeris - Molecular and Cellular …, 2020 - Elsevier
Neuroinflammation contributes to neurodegenerative disorders, including Alzheimer's
disease (AD). Gut microbes are involved in regulating systemic inflammation. Short-chain …
disease (AD). Gut microbes are involved in regulating systemic inflammation. Short-chain …
Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation
R Velazquez, E Ferreira, S Knowles, C Fux… - Aging cell, 2019 - Wiley Online Library
Currently, there are no effective therapies to ameliorate the pathological progression of
Alzheimer's disease (AD). Evidence suggests that environmental factors may contribute to …
Alzheimer's disease (AD). Evidence suggests that environmental factors may contribute to …
High-fat diet and aging interact to produce neuroinflammation and impair hippocampal-and amygdalar-dependent memory
SJ Spencer, H D'Angelo, A Soch, LR Watkins… - Neurobiology of …, 2017 - Elsevier
More Americans are consuming diets higher in saturated fats and refined sugars than ever
before, and based on increasing obesity rates, this is a growing trend among older adults as …
before, and based on increasing obesity rates, this is a growing trend among older adults as …