Adipose-derived mesenchymal stem cells therapy as a new treatment option for diabetes mellitus

A Mikłosz, A Chabowski - The Journal of Clinical Endocrinology …, 2023 - academic.oup.com
The worldwide increase in the prevalence of diabetes mellitus has raised the demand for
new therapeutic strategies targeting diabetic symptoms and its chronic complications …

Applicability of adipose-derived mesenchymal stem cells in treatment of patients with type 2 diabetes

Y Qi, J Ma, S Li, W Liu - Stem cell research & therapy, 2019 - Springer
Type 2 diabetes mellitus (T2DM) is mainly characterized by insulin resistance (IR) and
impaired insulin secretion. The chronic inflammatory process contributed to IR and could …

Regenerative and transplantation medicine: cellular therapy using adipose tissue-derived mesenchymal stromal cells for type 1 diabetes mellitus

H Takahashi, N Sakata, G Yoshimatsu… - Journal of clinical …, 2019 - mdpi.com
Type 1 diabetes mellitus (T1DM) is caused by the autoimmune targeting of pancreatic β-
cells, and, in the advanced stage, severe hypoinsulinemia due to islet destruction. In …

Using adipose‐derived mesenchymal stem cells to fight the metabolic complications of obesity: Where do we stand?

A Mikłosz, BE Nikitiuk, A Chabowski - Obesity Reviews, 2022 - Wiley Online Library
Obesity is a critical risk factor for the development of metabolic diseases, and its prevalence
is increasing worldwide. Stem cell‐based therapies have become a promising tool for …

Mesenchymal stem cells: an excellent candidate for the treatment of diabetes mellitus

Q Huang, Y Huang, J Liu - International Journal of …, 2021 - Wiley Online Library
Mesenchymal stem cells (MSCs) are adult stem cells (ASCs) known for repairing damaged
cells, exerting anti‐inflammatory responses and producing immunoregulatory effects that …

The roles of mesenchymal stem cell-derived exosomes in diabetes mellitus and its related complications

M Yang, J Chen, L Chen - Frontiers in Endocrinology, 2022 - frontiersin.org
Diabetes mellitus is a type of metabolic disease characterized by hyperglycemia, primarily
caused by defects in insulin secretion, insulin action, or both. Long-term chronic …

Adipose-derived mesenchymal stem cells ameliorate lipid metabolic disturbance in mice

GY Liu, J Liu, YL Wang, Y Liu, Y Shao… - Stem cells …, 2016 - academic.oup.com
Adipose-derived mesenchymal stem cells (AD-MSCs) have been shown to ameliorate
hyperglycemia in diabetic animals and individuals. However, little is known about whether …

Mesenchymal stem cell therapy in type 2 diabetes mellitus

L Zang, H Hao, J Liu, Y Li, W Han, Y Mu - Diabetology & metabolic …, 2017 - Springer
Type 2 diabetes mellitus (T2DM), which is characterized by the combination of relative
insulin deficiency and insulin resistance, cannot be reversed with existing therapeutic …

Mesenchymal stem cell-based therapy for diabetes mellitus: enhancement strategies and future perspectives

H Li, H Zhu, T Ge, Z Wang, C Zhang - Stem cell reviews and reports, 2021 - Springer
Diabetes mellitus (DM), a chronic disorder of carbohydrate metabolism, is characterized by
the unbridled hyperglycemia resulted from the impaired ability of the body to either produce …

Insulin-secreting adipose-derived mesenchymal stromal cells with bone marrow–derived hematopoietic stem cells from autologous and allogenic sources for type 1 …

UG Thakkar, HL Trivedi, AV Vanikar, SD Dave - Cytotherapy, 2015 - Elsevier
Background aims Stem cell therapy (SCT) is now the up-coming therapeutic modality for
treatment of type 1 diabetes mellitus (T1DM). Methods Our study was a prospective, open …