A compendium and comparative epigenomics analysis of cis-regulatory elements in the pig genome

Y Zhao, Y Hou, Y Xu, Y Luan, H Zhou, X Qi… - Nature …, 2021 - nature.com
Although major advances in genomics have initiated an exciting new era of research, a lack
of information regarding cis-regulatory elements has limited the genetic improvement or …

Pig genome functional annotation enhances the biological interpretation of complex traits and human disease

Z Pan, Y Yao, H Yin, Z Cai, Y Wang, L Bai… - Nature …, 2021 - nature.com
The functional annotation of livestock genomes is crucial for understanding the molecular
mechanisms that underpin complex traits of economic importance, adaptive evolution and …

A compendium of genetic regulatory effects across pig tissues

J Teng, Y Gao, H Yin, Z Bai, S Liu, H Zeng… - Nature …, 2024 - nature.com
Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …

PigBiobank: a valuable resource for understanding genetic and biological mechanisms of diverse complex traits in pigs

H Zeng, W Zhang, Q Lin, Y Gao, J Teng… - Nucleic acids …, 2024 - academic.oup.com
To fully unlock the potential of pigs as both agricultural species for animal-based protein
food and biomedical models for human biology and disease, a comprehensive …

A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription

L Jin, Q Tang, S Hu, Z Chen, X Zhou, B Zeng… - Nature …, 2021 - nature.com
A comprehensive transcriptomic survey of pigs can provide a mechanistic understanding of
tissue specialization processes underlying economically valuable traits and accelerate their …

Functional annotations of three domestic animal genomes provide vital resources for comparative and agricultural research

C Kern, Y Wang, X Xu, Z Pan, M Halstead… - Nature …, 2021 - nature.com
Gene regulatory elements are central drivers of phenotypic variation and thus of critical
importance towards understanding the genetics of complex traits. The Functional Annotation …

Mapping and analysis of a spatiotemporal H3K27ac and gene expression spectrum in pigs

Y Zhu, Z Zhou, T Huang, Z Zhang, W Li, Z Ling… - Science China Life …, 2022 - Springer
The limited knowledge of genomic noncoding and regulatory regions has restricted our
ability to decipher the genetic mechanisms underlying complex traits in pigs. In this study …

Enhancer-promoter interaction maps provide insights into skeletal muscle-related traits in pig genome

J Li, Y Xiang, L Zhang, X Qi, Z Zheng, P Zhou, Z Tang… - BMC biology, 2022 - Springer
Background Gene expression programs are intimately linked to the interplay of active cis
regulatory elements mediated by chromatin contacts and associated RNAs. Genome-wide …

An atlas of regulatory elements in chicken: A resource for chicken genetics and genomics

Z Pan, Y Wang, M Wang, Y Wang, X Zhu, S Gu… - Science …, 2023 - science.org
A comprehensive characterization of regulatory elements in the chicken genome across
tissues will have substantial impacts on both fundamental and applied research. Here, we …

A gene expression atlas of the domestic pig

TC Freeman, A Ivens, JK Baillie, D Beraldi, MW Barnett… - BMC biology, 2012 - Springer
Background This work describes the first genome-wide analysis of the transcriptional
landscape of the pig. A new porcine Affymetrix expression array was designed in order to …