Our ability to detect, image, and quantify nanoscopic objects and molecules with visible light
has undergone dramatic improvements over the past few decades. While fluorescence has …

Dark field microscopy directly detects scattering from a sample by rejecting excitation light.
The technique has been extensively used for spectral characterization of nanoscopic …

Recently dark-field microscopy and Rayleigh scattering spectroscopy have emerged as
complementary technologies for ultrasensitive biological detection and imaging with high …

Self-luminous substances such as phosphorescent organisms and chemiluminescent
objects are ideal samples to observe under DFM. In such cases, no exogenous light source …

Fluorescence microscopy has been the workhorse for investigating optical phenomena at
the nanometer scale but this approach confronts several fundamental limits. As a result …

The spectroscopic characterization of individual nanostructures is of fundamental
importance to understanding a broad range of physical and chemical processes. One …

Advances in plasmonic nanoparticle synthesis afford new opportunities for biosensing
applications. Here, we apply a combination of a new type of plasmonic nanomaterial …

Optical imaging represents one of the most essential tools in biological studies. Although
with great advances, bio-optical imaging still suffers from problems such as resolution …

The greatly enhanced fields near metal nanoparticles have demonstrated remarkable
optical properties and are promising for applications from solar energy to biosensing …

Recent development in total internal reflection fluorescence microscopy (TIRFM) has made it
possible to directly monitor the behaviors of biomolecules at the single-molecule level both …