CRISPR/Cas-powered nanobiosensors for diagnostics

QA Phan, LB Truong, D Medina-Cruz, C Dincer… - Biosensors and …, 2022 - Elsevier
CRISPR diagnostics (CRISPR-Dx) offer a wide range of enhancements compared to
traditional nanobiosensors by taking advantage of the excellent trans-cleavage activity of the …

CRISPR/Cas-engineered technology: Innovative approach for biosensor development

TS Zavvar, Z Khoshbin, M Ramezani… - Biosensors and …, 2022 - Elsevier
On-site and real-time clinical monitoring have been progressed dramatically by integrating
biosensor science with portable digital electronic technology. Clustered regularly …

Advancing sensing technology with CRISPR: From the detection of nucleic acids to a broad range of analytes–a review

S Xie, Z Ji, T Suo, B Li, X Zhang - Analytica Chimica Acta, 2021 - Elsevier
The CRISPR/Cas technology, derived from an adaptive immune system in bacteria, has
been awarded the Nobel Prize in Chemistry in 2020 for its success in gene editing …

CRISPR/Cas Systems‐Inspired Nano/Biosensors for Detecting Infectious Viruses and Pathogenic Bacteria

X Zhang, Y Shi, G Chen, D Wu, Y Wu, G Li - Small Methods, 2022 - Wiley Online Library
Infectious pathogens cause severe human illnesses and great deaths per year worldwide.
Rapid, sensitive, and accurate detection of pathogens is of great importance for preventing …

Advancements in CRISPR-based biosensing for next-gen point of care diagnostic application

A Kumaran, N Jude Serpes, T Gupta, A James… - Biosensors, 2023 - mdpi.com
With the move of molecular tests from diagnostic labs to on-site testing becoming more
common, there is a sudden rise in demand for nucleic acid-based diagnostic tools that are …

CRISPR-based biosensors for pathogenic biosafety

H Yang, R Ledesma-Amaro, H Gao, Y Ren… - Biosensors and …, 2023 - Elsevier
Pathogenic biosafety is a worldwide concern. Tools for analyzing pathogenic biosafety, that
are precise, rapid and field-deployable, are highly demanded. Recently developed …

Exploring the trans-cleavage activity of CRISPR/Cas12a on gold nanoparticles for stable and sensitive biosensing

X Fu, Y Shi, F Peng, M Zhou, Y Yin, Y Tan… - Analytical …, 2021 - ACS Publications
Taking advantage of the excellent trans-cleavage activity, CRISPR-based diagnostics
(CRISPR-Dx) has shown great promise in molecular diagnostics. However, the single …

Gold nanomaterials‐implemented CRISPR‐Cas systems for biosensing

R Fu, Y Xianyu - Small, 2023 - Wiley Online Library
Due to their superiority in the simple design and precise targeting, clustered regularly
interspaced short palindromic repeats (CRISPR)‐Cas systems have attracted significant …

CRISPR-based biosensing strategies: technical development and application prospects

T Tian, X Zhou - Annual Review of Analytical Chemistry, 2023 - annualreviews.org
Biosensing based on CRISPR-Cas systems is a young but rapidly evolving technology. The
unprecedented properties of the CRISPR-Cas system provide an innovative tool for …

Novel non-nucleic acid targets detection strategies based on CRISPR/Cas toolboxes: A review

X Cheng, Y Li, J Kou, D Liao, W Zhang, L Yin… - Biosensors and …, 2022 - Elsevier
Various non-nucleic acid targets (ions, small molecules, polysaccharides, peptides/proteins/
enzymes, cells, transcription factors) are important biomarkers. They play important roles in …