Genetics of substance use disorders: a review
JD Deak, EC Johnson - Psychological medicine, 2021 - cambridge.org
Substance use disorders (SUDs) are prevalent and result in an array of negative
consequences. They are influenced by genetic factors (h2=~ 50%). Recent years have …
consequences. They are influenced by genetic factors (h2=~ 50%). Recent years have …
Genetic overlap and causality between substance use disorder and attention‐deficit and hyperactivity disorder
L Vilar‐Ribó, C Sánchez‐Mora, P Rovira… - American Journal of …, 2021 - Wiley Online Library
Substance use disorder (SUD) often co‐occur at high prevalence with other psychiatric
conditions. Among them, attention‐deficit and hyperactivity disorder (ADHD) is present in …
conditions. Among them, attention‐deficit and hyperactivity disorder (ADHD) is present in …
Molecular genetics of substance use disorders: An umbrella review
S Lopez-Leon, Y Gonzalez-Giraldo… - Neuroscience & …, 2021 - Elsevier
Background Substance use disorders (SUD) are a category of psychiatric disorders with a
large epidemiological and societal impact around the world. In the last decades, a large …
large epidemiological and societal impact around the world. In the last decades, a large …
Psychometric and genetic architecture of substance use disorder and behavioral disinhibition measures for gene association studies
Using large twin, family, and adoption studies conducted at the Minnesota Center for Twin
and Family Research, we describe our efforts to develop measures of substance use …
and Family Research, we describe our efforts to develop measures of substance use …
Genetics of substance use disorders in the era of big data
J Gelernter, R Polimanti - Nature Reviews Genetics, 2021 - nature.com
Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
Common single nucleotide variants underlying drug addiction: more than a decade of research
Drug‐related phenotypes are common complex and highly heritable traits. In the last few
years, candidate gene (CGAS) and genome‐wide association studies (GWAS) have …
years, candidate gene (CGAS) and genome‐wide association studies (GWAS) have …
The genetic epidemiology of substance use disorder: A review
EC Prom-Wormley, J Ebejer, DM Dick… - Drug and alcohol …, 2017 - Elsevier
Background Substance use disorder (SUD) remains a significant public health issue. A
greater understanding of how genes and environment interact to regulate phenotypes …
greater understanding of how genes and environment interact to regulate phenotypes …
Genome‐wide association studies of alcohol dependence, DSM‐IV criterion count and individual criteria
Genome‐wide association studies (GWAS) of alcohol dependence (AD) have reliably
identified variation within alcohol metabolizing genes (eg, ADH1B) but have inconsistently …
identified variation within alcohol metabolizing genes (eg, ADH1B) but have inconsistently …
Recent efforts to dissect the genetic basis of alcohol use and abuse
Alcohol use disorder (AUD) is defined by several symptom criteria, which can be dissected
further at the genetic level. Over the past several years, our understanding of the genetic …
further at the genetic level. Over the past several years, our understanding of the genetic …
Genetics of alcohol use disorder: a review
Alcohol use disorder (AUD) represents a significant and ongoing public health concern with
12-month prevalence estimates of∼ 5.6%. Quantitative genetic studies suggest a heritability …
12-month prevalence estimates of∼ 5.6%. Quantitative genetic studies suggest a heritability …