During ontogeny, γδ T cells emerge from the thymus and directly seed peripheral tissues for
in situ immunity. However, their functional role in humans has largely been defined from …

Abstract γδ T cells perform heterogeneous functions in homeostasis and disease across
tissues. However, it is unclear whether these roles correspond to distinct γδ subsets or to a …

The complexity of the human immune system is exacerbated by age-related changes to
immune cell functionality. Many of these age-related effects remain undescribed or driven by …

Circulating immune cell compartments have been extensively studied for decades, but
limited access to peripheral tissue and cell yield have hampered our understanding of tissue …

Phenotypic and functional heterogeneity are the hallmarks of effector and memory T cells.
Upon antigen stimulation, γδ T cells differentiate into two major types of memory T cells …

Under non-pathological conditions, human γδ T cells represent a small fraction of CD3+ T
cells in peripheral blood (1-10%). They constitute a unique subset of T lymphocytes that …

The distinct characteristics of γδ T cells determine their vital roles in the formation of local
immune responses and contribute to tissue homeostasis. However, the heterogeneity of γδ T …

Cellular & Molecular Immunology (2018) 15, 411–413; doi: 10.1038/cmi. 2017.73; published
online 28 August 2017 γδ T cells were first identified as a novel T-cell subset in the 1980s. 1 …

Summary γδ T cells are generally considered innate-like lymphocytes, however, an"
adaptive-like" γδ compartment has now emerged. To understand transcriptional regulation …

T cell receptors consist either of an α-chain combined with a β-chain or a γ-chain combined
with a δ-chain. αβ T cells constitute the majority of T cells in human blood throughout life …