Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span
During ontogeny, γδ T cells emerge from the thymus and directly seed peripheral tissues for
in situ immunity. However, their functional role in humans has largely been defined from …
in situ immunity. However, their functional role in humans has largely been defined from …
[HTML][HTML] Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice
A Du Halgouet, K Bruder, N Peltokangas… - Nature …, 2024 - nature.com
Abstract γδ T cells perform heterogeneous functions in homeostasis and disease across
tissues. However, it is unclear whether these roles correspond to distinct γδ subsets or to a …
tissues. However, it is unclear whether these roles correspond to distinct γδ subsets or to a …
[HTML][HTML] A Cell for the Ages: Human γδ T Cells across the Lifespan
BL Clark, PG Thomas - International journal of molecular sciences, 2020 - mdpi.com
The complexity of the human immune system is exacerbated by age-related changes to
immune cell functionality. Many of these age-related effects remain undescribed or driven by …
immune cell functionality. Many of these age-related effects remain undescribed or driven by …
[HTML][HTML] Comparing mouse and human tissue-resident γδ T cells
G Qu, S Wang, Z Zhou, D Jiang, A Liao… - Frontiers in …, 2022 - frontiersin.org
Circulating immune cell compartments have been extensively studied for decades, but
limited access to peripheral tissue and cell yield have hampered our understanding of tissue …
limited access to peripheral tissue and cell yield have hampered our understanding of tissue …
Mechanisms underlying lineage commitment and plasticity of human γδ T cells
Phenotypic and functional heterogeneity are the hallmarks of effector and memory T cells.
Upon antigen stimulation, γδ T cells differentiate into two major types of memory T cells …
Upon antigen stimulation, γδ T cells differentiate into two major types of memory T cells …
[HTML][HTML] Deep characterization of human γδ T cell subsets defines shared and lineage-specific traits
Under non-pathological conditions, human γδ T cells represent a small fraction of CD3+ T
cells in peripheral blood (1-10%). They constitute a unique subset of T lymphocytes that …
cells in peripheral blood (1-10%). They constitute a unique subset of T lymphocytes that …
[HTML][HTML] Single-cell RNA-seq and chromatin accessibility profiling decipher the heterogeneity of mouse γδ T cells
Z Li, Q Yang, X Tang, Y Chen, S Wang, X Qi, Y Zhang… - Science bulletin, 2022 - Elsevier
The distinct characteristics of γδ T cells determine their vital roles in the formation of local
immune responses and contribute to tissue homeostasis. However, the heterogeneity of γδ T …
immune responses and contribute to tissue homeostasis. However, the heterogeneity of γδ T …
Human regulatory γδT cells and their functional plasticity in the tumor microenvironment
H Chen, W He - Cellular & Molecular Immunology, 2018 - nature.com
Cellular & Molecular Immunology (2018) 15, 411–413; doi: 10.1038/cmi. 2017.73; published
online 28 August 2017 γδ T cells were first identified as a novel T-cell subset in the 1980s. 1 …
online 28 August 2017 γδ T cells were first identified as a novel T-cell subset in the 1980s. 1 …
[HTML][HTML] Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program
JL McMurray, A von Borstel, TE Taher, E Syrimi… - Cell reports, 2022 - cell.com
Summary γδ T cells are generally considered innate-like lymphocytes, however, an"
adaptive-like" γδ compartment has now emerged. To understand transcriptional regulation …
adaptive-like" γδ compartment has now emerged. To understand transcriptional regulation …
Ontogeny of γδ T cells in humans
SC De Rosa, JP Andrus, SP Perfetto… - The Journal of …, 2004 - journals.aai.org
T cell receptors consist either of an α-chain combined with a β-chain or a γ-chain combined
with a δ-chain. αβ T cells constitute the majority of T cells in human blood throughout life …
with a δ-chain. αβ T cells constitute the majority of T cells in human blood throughout life …