In human demyelinating diseases such as multiple sclerosis (MS), an imbalance between
demyelination and remyelination can trigger progressive degenerative processes. The …

Recent evidence suggests that astrocytes play an important role in regulating de-and
remyelination in multiple sclerosis. The role of astrocytes is controversial, and both …

Although astrogliosis and microglia activation are characteristic features of multiple sclerosis
(MS) and other central nervous system (CNS) lesions the exact functions of these events are …

In multiple sclerosis, endogenous oligodendrocyte precursor cells (OPCs) attempt to
remyelinate areas of myelin damage. During disease progression, however, these attempts …

An imbalance between remyelinating and demyelinating rates underlies degenerative
processes in demyelinating diseases such as multiple sclerosis. An optimal therapeutic …

In multiple sclerosis (MS), gray matter pathology is characterized by less pronounced
inflammation when compared with white matter lesions. Although regional differences in the …

To study microglial/macrophage infiltration, a cuprizone-induced model for demyelination in
C57BL/6 mice was established. Cuprizone is known to cause demyelination in Swiss mice …

Microglia are resident macrophages of the CNS that are involved in its development,
homeostasis and response to infection and damage. Microglial activation is a common …

In multiple sclerosis, microglia/macrophage activation and astrocyte reactivity are important
components of the lesion environment that can impact remyelination. The current study …

Interactions between microglia, the resident macrophages of the central nervous system
(CNS), and myelin, the glial sheath on nerve fibers essential for rapid neural impulse …