A multi-organ systems model of O2 and CO2 transport is developed to analyze the control of
ventilation and blood flow during hypoxia. Among the aspects of the control processes that …

A comprehensive model of oxygen (O 2) and carbon dioxide (CO 2) exchange, transport,
and storage in the adult human is presented, and its ability to provide realistic responses …

Liang, Pei-Ji, Daphne A. Bascom, and Peter A. Robbins. Extended models of the ventilatory
response to sustained isocapnic hypoxia in humans. J. Appl. Physiol. 82 (2): 667–677, 1997 …

This work presents a mathematical model of the human respiratory control system, based on
physiological knowledge. It includes three compartments for gas storage and exchange …

The mathematical model of the respiratory control system described in a previous
companion paper is used to analyse the ventilatory response to hypoxic stimuli. Simulation …

While it is known that cerebral blood flow is increased by hypoxia (5), the dynamics of the
cerebral blood flow response to hypoxia have not yet been adequately described. This is …

Maintenance of an adequate supply of O 2 to tissues depends on a complex pattern of
circulatory and ventilatory adjustments that are triggered by environmental perturbations …

This paper uses a steady-state modeling approach to describe the effects of changes in acid-
base balance on the chemoreflex control of breathing. First, a mathematical model is …

Hypoxia induces unstable breathing such as Cheyne-Stokes breathing primarily through the
increase in the peripheral chemoreceptor gain to C02. Another consequence of hypoxia …

A mathematical model portraying a humoral signal derived from time-dependent variations
in arterial carbon dioxide tension (PaCO2) and a neural signal proportional to the metabolic …