[PDF][PDF] Role of necroptosis in spinal cord injury and its therapeutic implications

J Fu, C Wu, G Xu, J Zhang, Y LI, C Ji, Z Cui - Biocell, 2023 - cdn.techscience.cn
Spinal cord injury (SCI), a complex neurological disorder, triggers a series of devastating
neuropathological events such as ischemia, oxidative stress, inflammatory events, neuronal …

Mechanism and disease implications of necroptosis and neuronal inflammation

SR Oliveira, JD Amaral, CMP Rodrigues - Cell death & disease, 2018 - nature.com
Necroptosis is a form of regulated necrotic cell death, executed via activation of receptor-
interacting protein 1 (RIP1) and 3 (RIP3), which is activated under apoptosisdeficient …

[HTML][HTML] Role of necroptosis in traumatic brain and spinal cord injuries

X Hu, Y Xu, H Zhang, Y Li, X Wang, C Xu, W Ni… - Journal of Advanced …, 2022 - Elsevier
Background Traumatic brain injury (TBI) and spinal cord injury (SCI) are capable of causing
severe sensory, motor and autonomic nervous system dysfunctions. However, effective …

Upregulation of the receptor-interacting protein 3 expression and involvement in neural tissue damage after spinal cord injury in mice

H Kanno, H Ozawa, S Tateda, K Yahata, E Itoi - BMC neuroscience, 2015 - Springer
Background Necroptosis is a newly identified type of programmed cell death that differs from
apoptosis. Recent studies have demonstrated that necroptosis is involved in multiple …

Necroptosis in neurodegenerative diseases: a potential therapeutic target

S Zhang, M Tang, H Luo, C Shi, Y Xu - Cell death & disease, 2017 - nature.com
Neurodegenerative diseases are a group of chronic progressive disorders characterized by
neuronal loss. Necroptosis, a recently discovered form of programmed cell death, is a cell …

Necroptosis in CNS diseases: Focus on astrocytes

EV Mitroshina, M Saviuk, MV Vedunova - Frontiers in Aging …, 2023 - frontiersin.org
In the last few years, necroptosis, a recently described type of cell death, has been reported
to play an important role in the development of various brain pathologies. Necroptosis is a …

Unwinding the modalities of necrosome activation and necroptosis machinery in neurological diseases

R Gupta, S Kumari, R Tripathi, RK Ambasta… - Ageing Research …, 2023 - Elsevier
Necroptosis, a regulated form of cell death, is involved in the genesis and development of
various life-threatening diseases, including cancer, neurological disorders, cardiac …

Molecular mechanisms of necroptosis and relevance for neurodegenerative diseases

PA Dionísio, JD Amaral, CMP Rodrigues - International Review of Cell and …, 2020 - Elsevier
Necroptosis is a regulated cell death pathway morphologically similar to necrosis that
depends on the kinase activity of receptor interacting protein 3 (RIP3) and the subsequent …

Necroptosis, a novel type of programmed cell death, contributes to early neural cells damage after spinal cord injury in adult mice

M Liu, W Wu, H Li, S Li, L Huang, Y Yang… - The journal of spinal …, 2015 - Taylor & Francis
Background Necroptosis is an emerging programmed necrosis other than traditional
necrosis and apoptosis. Until recently, there have not been studies that have investigated a …

[HTML][HTML] RIP3 inhibition protects locomotion function through ameliorating mitochondrial antioxidative capacity after spinal cord injury

Y Wang, J Jiao, S Zhang, C Zheng, M Wu - Biomedicine & …, 2019 - Elsevier
A novel type of programmed necrosis called necroptosis has been identified in the field of
cell death, thereby offering an opportunity for re-examining necrosis after spinal cord injury …