Tiny earth: a big idea for STEM education and antibiotic discovery

A Hurley, MG Chevrette, DD Acharya, GL Lozano… - MBio, 2021 - Am Soc Microbiol
The world faces two seemingly unrelated challenges—a shortfall in the STEM workforce and
increasing antibiotic resistance among bacterial pathogens. We address these two …

Antibiotic discovery throughout the Small World Initiative: a molecular strategy to identify biosynthetic gene clusters involved in antagonistic activity

E Davis, T Sloan, K Aurelius, A Barbour… - …, 2017 - Wiley Online Library
The emergence of bacterial pathogens resistant to all known antibiotics is a global health
crisis. Adding to this problem is that major pharmaceutical companies have shifted away …

[HTML][HTML] Adjuncts and alternatives in the time of antibiotic resistance and in‐feed antibiotic bans

H Brüssow - Microbial biotechnology, 2017 - ncbi.nlm.nih.gov
At first glance, it might surprise when an editorial series in a scientific journal asks how
science will help to create companies and jobs. However, a recent 'Nature'editorial has …

Antibiotic discovery is a walk in the park

LF Nothias, R Knight… - Proceedings of the …, 2016 - National Acad Sciences
Can you imagine New York's Central Park as a source of the next generation of antibiotics
that can treat hundreds of millions of people? The work by Charlop-Powers et al. in PNAS …

Educating in antimicrobial resistance awareness: adaptation of the Small World Initiative program to service-learning

MJ Valderrama, B González-Zorn… - FEMS microbiology …, 2018 - academic.oup.com
Abstract The Small World Initiative (SWI) and Tiny Earth are a consolidated and successful
education programs rooted in the USA that tackle the antibiotic crisis by a crowdsourcing …

Goodbye to brute force in antibiotic discovery?

R Kolter, GP Van Wezel - Nature microbiology, 2016 - nature.com
The discovery and development of antibiotics to fight bacterial diseases is one of the great
triumphs in modern medicine. However, the rapid spread of resistance to antibiotics …

[HTML][HTML] Seeking new antibiotics in nature's backyard

A Von Bubnoff - Cell, 2006 - cell.com
Seeking New Antibiotics in Nature's Backyard: Cell Skip to Main Content Skip to Main Menu
Advertisement Cell This journal offers authors two options (open access or subscription) to …

Roadmap for antibiotic discovery

CK Shore, A Coukell - Nature microbiology, 2016 - nature.com
There are no antibiotic candidates simply waiting to be brought to market. Overcoming the
scientific barriers to innovation will require research and coordination beyond anything that …

Why do antibiotics exist?

F Spagnolo, M Trujillo, JJ Dennehy - MBio, 2021 - Am Soc Microbiol
In the struggle with antibiotic resistance, we are losing. There is now a serious threat of
moving into a postantibiotic world. High levels of resistance, in terms of both frequency and …

How to stimulate and facilitate early stage antibiotic discovery

J Zuegg, KA Hansford, AG Elliott… - ACS infectious …, 2020 - ACS Publications
The discovery of novel antibiotics is essential to combat the rise of antimicrobial resistance.
While a number of initiatives are focused on advancing promising leads into the clinic, there …