Atomic structure of Lanreotide nanotubes revealed by cryo-EM

L Pieri, F Wang, AA Arteni, M Vos… - Proceedings of the …, 2022 - National Acad Sciences
Functional and versatile nano-and microassemblies formed by biological molecules are
found at all levels of life, from cell organelles to full organisms. Understanding the chemical …

[HTML][HTML] Molecular origin of the self-assembly of lanreotide into nanotubes: a mutational approach

C Valéry, E Pouget, A Pandit, JM Verbavatz, L Bordes… - Biophysical …, 2008 - cell.com
Lanreotide, a synthetic, therapeutic octapeptide analog of somatostatin, self-assembles in
water into perfectly hollow and monodisperse (24-nm wide) nanotubes. Lanreotide is a …

Elucidation of the self-assembly pathway of lanreotide octapeptide into β-sheet nanotubes: role of two stable intermediates

E Pouget, N Fay, E Dujardin, N Jamin… - Journal of the …, 2010 - ACS Publications
Nanofabrication by molecular self-assembly involves the design of molecules and self-
assembly strategies so that shape and chemical complementarities drive the units to …

Self‐assembly of the octapeptide lanreotide and lanreotide‐based derivatives: the role of the aromatic residues

A Pandit, N Fay, L Bordes, C Valéry… - Journal of Peptide …, 2008 - Wiley Online Library
We investigated the spectroscopic properties of the aromatic residues in a set of
octapeptides with various self‐assembly properties. These octapeptides are based on …

Experimental observation of double-walled peptide nanotubes and monodispersity modeling of the number of walls

F Gobeaux, N Fay, C Tarabout, F Meneau, C Mériadec… - Langmuir, 2013 - ACS Publications
Self-assembled nanoarchitectures based on biological molecules are attractive because of
the simplicity and versatility of the building blocks. However, size control is still a challenge …

Peptide nanotubes: molecular organisations, self-assembly mechanisms and applications

C Valéry, F Artzner, M Paternostre - Soft Matter, 2011 - pubs.rsc.org
Peptide nanotubes are promising bio-inspired self-assemblies with a wide range of
envisioned applications. The present review addresses the recent advances in their …

Biomimetic organization: Octapeptide self-assembly into nanotubes of viral capsid-like dimension

C Valéry, M Paternostre, B Robert… - Proceedings of the …, 2003 - National Acad Sciences
The controlled self-assembly of complex molecules into well defined hierarchical structures
is a promising route for fabricating nanostructures. These nanoscale structures can be …

Peptide nanotubes and beyond

JD Hartgerink, TD Clark… - Chemistry–A European …, 1998 - Wiley Online Library
Self‐assembling peptide nanotubes (such as the cyclic peptide for which the calculated
crystal structure is shown on the right) display a wide range of structural and functional …

[HTML][HTML] Self-association process of a peptide in solution: from β-sheet filaments to large embedded nanotubes

C Valery, F Artzner, B Robert, T Gulick, G Keller… - Biophysical journal, 2004 - cell.com
Lanreotide is a synthetic octapeptide used in the therapy against acromegaly. When mixed
with pure water at 10%(w/w), Lanreotide (acetate salt) forms liquid crystalline and …

A new motif in the formation of peptide nanotubes: The crystallographic signature

S Ray, D Haldar, MGB Drew, A Banerjee - Organic Letters, 2004 - ACS Publications
Terminally protected acyclic tripeptides Boc-Tyr (1)-Val (2)-Tyr (3)-OMe 1 and Boc-Tyr (1)-Ile
(2)-Tyr (3)-OMe 2 self-assemble into nanotubes in crystals through various noncovalent …