The aging heart and post-infarction left ventricular remodeling

H Shih, B Lee, RJ Lee, AJ Boyle - Journal of the American College of …, 2011 - jacc.org
Aging is a risk factor for heart failure, which is a leading cause of death world-wide. Elderly
patients are more likely than young patients to experience a myocardial infarction (MI) and …

Cardiac tissue remodeling in healthy aging: the road to pathology

E Tracy, G Rowe, AJ LeBlanc - American Journal of …, 2020 - journals.physiology.org
This review aims to highlight the normal physiological remodeling that occurs in healthy
aging hearts, including changes that occur in contractility, conduction, valve function, large …

The aging heart

V Obas, RS Vasan - Clinical Science, 2018 - portlandpress.com
As the elderly segment of the world population increases, it is critical to understand the
changes in cardiac structure and function during the normal aging process. In this review …

Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence

NA Gude, KM Broughton, F Firouzi… - Nature Reviews …, 2018 - nature.com
Cardiac ageing manifests as a decline in function leading to heart failure. At the cellular
level, ageing entails decreased replicative capacity and dysregulation of cellular processes …

Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications

S Xie, SC Xu, W Deng, Q Tang - Signal Transduction and Targeted …, 2023 - nature.com
Cardiac aging is evident by a reduction in function which subsequently contributes to heart
failure. The metabolic microenvironment has been identified as a hallmark of malignancy …

Cardiomyocyte ageing and cardioprotection: consensus document from the ESC working groups cell biology of the heart and myocardial function

M Ruiz-Meana, D Bou-Teen… - Cardiovascular …, 2020 - academic.oup.com
Advanced age is a major predisposing risk factor for the incidence of coronary syndromes
and comorbid conditions which impact the heart response to cardioprotective interventions …

Aging and autophagy in the heart

A Shirakabe, Y Ikeda, S Sciarretta, DK Zablocki… - Circulation …, 2016 - Am Heart Assoc
The aging population is increasing in developed countries. Because the incidence of
cardiac disease increases dramatically with age, it is important to understand the molecular …

A review of the molecular mechanisms underlying the development and progression of cardiac remodeling

L Schirone, M Forte, S Palmerio, D Yee… - Oxidative medicine …, 2017 - Wiley Online Library
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …

[HTML][HTML] Cardiomyocyte senescence and cellular communications within myocardial microenvironments

X Tang, PH Li, HZ Chen - Frontiers in endocrinology, 2020 - frontiersin.org
Cardiovascular diseases have become the leading cause of human death. Aging is an
independent risk factor for cardiovascular diseases. Cardiac aging is associated with …

[HTML][HTML] The aging heart: mitophagy at the center of rejuvenation

WJ Liang, ÅB Gustafsson - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Aging is associated with structural and functional changes in the heart and is a major risk
factor in developing cardiovascular disease. Many recent studies have focused on …