An ideal brain-targeted nanocarrier must be sufficiently potent to penetrate the blood–brain
barrier (BBB) and sufficiently competent to target the cells of interest with adequate …

Therapeutic outcome for the treatment of glioma was often limited due to the non-targeted
nature of drugs and the physiological barriers, including the blood-brain barrier (BBB) and …

An ideal nano drug delivery agent must be potent enough to carry high dose of therapeutics
and competent enough in targeting specific cell of interest, having adequate optimized …

Glioblastoma multiforme (GBM) is a grade IV astrocytoma, which is the most aggressive form
of brain tumor. The standard of care for this disease includes surgery, radiotherapy and …

Background Ferritin, the natural iron storage protein complex, self-assembles into a uniform
cage-like structure. Human H-ferritin (HFn) has been shown to transverse the blood–brain …

Introduction: As a protein-based biomaterial for potential cancer targeting delivery,
apoferritin has recently attracted interest. Areas covered: In this review, we discuss the …

Achieving effective drug delivery to traverse the blood–brain barrier (BBB) and target tumor
cells remains the greatest challenge for brain tumor therapy. Importantly, the overexpressed …

Due to many adverse effects of conventional chemotherapy, novel methods of targeting
drugs to cancer cells are being investigated. Nanosize carriers are a suitable platform for …

In this paper, we proposed a naturally derived protein cage based pH-responsive delivery
system for intracellular prodrug controlled release. The drug delivery system is based on …

Ferritin (FRT) is a major iron storage protein found in humans and most living organisms.
Each ferritin is composed of 24 subunits, which self-assemble to form a cage-like …