Aversion refers to feelings of strong dislike or avoidance toward particular stimuli or
situations. Aversion can be caused by pain stimuli and has a long-term negative impact on …

Conditioned place avoidance (CPA) paradigm has been used to investigate the affective
component of pain. Although the anterior cingulate cortex (ACC) has been demonstrated to …

Background Some studies have highlighted the crucial role of aversion in addiction
treatment. The pathway from the anterior paraventricular thalamus (PVT) to the shell of the …

We examined the role of glutamatergic transmission within the basolateral amygdaloid
nucleus (BLA) in pain-induced aversion using a conditioned place paradigm and an in vivo …

Chronic pain conditions within clinical populations are correlated with a high incidence of
depression, and researchers have reported their high rate of comorbidity. Clinically, chronic …

Pain consists of sensory discriminative and negative affective components. Although the
neural systems responsible for the sensory component of pain have been studied …

Pain is comprised of both sensory and affective components. The anterior cingulate cortex
(ACC) is a key brain region involved in the emotional processing of pain. Specifically …

The periaqueductal gray (PAG) is a significant modulator of both analgesic and fear
behaviors in both humans and rodents, but the underlying circuitry responsible for these two …

A negative emotional state resulting from the withdrawal of drug addiction is thought to be an
important factor that triggers and exacerbates relapse. Since the insular cortex is a key brain …

The ventrolateral periaqueductal gray (vlPAG) collaborates with the dorsal raphe (DR) in
pain regulation and emotional response. However, the roles of vlPAG and DR γ …