Dysfunction of FadA‐cAMP signalling decreases Aspergillus flavus resistance to antimicrobial natural preservative Perillaldehyde and AFB1 biosynthesis

K Yang, Q Geng, Y Luo, R Xie, T Sun… - Environmental …, 2022 - Wiley Online Library
Aspergillus flavus is an opportunistic fungal pathogen that colonizes agriculture crops with
aflatoxin contamination. We found that Perillaldehyde (PAE) effectively inhibited A. flavus …

The Antioxidant Gallic Acid Inhibits Aflatoxin Formation in Aspergillus flavus by Modulating Transcription Factors FarB and CreA

X Zhao, QQ Zhi, JY Li, NP Keller, ZM He - Toxins, 2018 - mdpi.com
Aflatoxin biosynthesis is correlated with oxidative stress and is proposed to function as a
secondary defense mechanism to redundant intracellular reactive oxygen species (ROS) …

The Master Transcription Factor mtfA Governs Aflatoxin Production, Morphological Development and Pathogenicity in the Fungus Aspergillus flavus

Z Zhuang, JM Lohmar, T Satterlee, JW Cary, AM Calvo - Toxins, 2016 - mdpi.com
Aspergillus flavus produces a variety of toxic secondary metabolites; among them, the
aflatoxins (AFs) are the most well known. These compounds are highly mutagenic and …

Responses of Aspergillus flavus to Oxidative Stress Are Related to Fungal Development Regulator, Antioxidant Enzyme, and Secondary Metabolite Biosynthetic …

JC Fountain, P Bajaj, SN Nayak, L Yang… - Frontiers in …, 2016 - frontiersin.org
The infection of maize and peanut with Aspergillus flavus and subsequent contamination
with aflatoxin pose a threat to global food safety and human health, and is exacerbated by …

Piperine inhibits aflatoxin B1 production in Aspergillus flavus by modulating fungal oxidative stress response

I Caceres, R El Khoury, S Bailly, IP Oswald… - Fungal Genetics and …, 2017 - Elsevier
Aspergillus flavus, a soil-borne pathogen, represents a danger for humans and animals
since it produces the carcinogenic mycotoxin Aflatoxin B1 (AFB1). Approaches aiming the …

New insights of transcriptional regulator AflR in Aspergillus flavus physiology

P Wang, J Xu, PK Chang, Z Liu, Q Kong - Microbiology Spectrum, 2022 - Am Soc Microbiol
Aspergillus flavus aflR, a gene encoding a Zn (II) 2Cys6 DNA-binding domain, is an
important transcriptional regulator of the aflatoxin biosynthesis gene cluster. Our previous …

The inhibitory effect of Bacillus megaterium on aflatoxin and cyclopiazonic acid biosynthetic pathway gene expression in Aspergillus flavus

Q Kong, C Chi, J Yu, S Shan, Q Li, Q Li, B Guan… - Applied microbiology …, 2014 - Springer
Aspergillus flavus is one of the major moulds that colonize peanut in the field and during
storage. The impact to human and animal health, and to the economy in agriculture and …

Regulation of aflatoxin synthesis by FadA/cAMP/protein kinase A signaling in Aspergillus parasiticus

LV Roze, RM Beaudry, NP Keller, JE Linz - Mycopathologia, 2004 - Springer
Abstract Analysis of fadA and pkaA mutants in the filamentous fungus Aspergillus nidulans
demonstrated that FadA (Gα) stimulates cyclic AMP (cAMP)-dependent protein kinase A …

Aflatoxins are natural scavengers of reactive oxygen species

E Finotti, A Parroni, M Zaccaria, M Domin, B Momeni… - Scientific Reports, 2021 - nature.com
The role of aflatoxins (AFs) in the biology of producing strains, Aspergillus sect. Flavi, is still
a matter of debate. Over recent years, research has pointed to how environmental factors …

Adenylate Cyclase AcyA Regulates Development, Aflatoxin Biosynthesis and Fungal Virulence in Aspergillus flavus

K Yang, Q Qin, Y Liu, L Zhang, L Liang… - Frontiers in Cellular …, 2016 - frontiersin.org
Aspergillus flavus is one of the most important opportunistic pathogens of crops and
animals. The carcinogenic mycotoxin, aflatoxins produced by this pathogen cause a health …