Disseminated cryptococcosis with brain involvement in patients with chronic lymphoid malignancies on ibrutinib

JA Messina, EK Maziarz, A Spec… - Open forum …, 2017 - academic.oup.com
We report 2 cases of disseminated cryptococcosis with central nervous system involvement
in patients with chronic lymphoid malignancies occurring within 1 month of starting on …

Disseminated cryptococcal disease in a patient with chronic lymphocytic leukemia on ibrutinib

K Okamoto, LA Proia… - Case reports in infectious …, 2016 - Wiley Online Library
Cryptococcus is a unique environmental fungus that can cause disease most often in
immunocompromised individuals with defective cell‐mediated immunity. Chronic …

Cryptococcal infections in two patients receiving ibrutinib therapy for chronic lymphocytic leukemia

M Stankowicz, M Banaszynski… - Journal of Oncology …, 2019 - journals.sagepub.com
Cryptococcal infections are responsible for significant morbidity and mortality in
immunocompromised patients. Reports of these infections in patients on small molecular …

Ibrutinib, a Bruton's tyrosine kinase inhibitor, a new risk factor for cryptococcosis

J Brochard, F Morio, J Mahe, P Le Pape… - Medecine et Maladies …, 2020 - Elsevier
Purpose Invasive fungal diseases and especially Cryptococcus neoformans infections are
increasingly reported in patients with hematological malignancies receiving ibrutinib, a …

Fungal infections in patients treated with ibrutinib: two unusual cases of invasive aspergillosis and cryptococcal meningoencephalitis

M Baron, JM Zini, T Challan Belval, M Vignon… - Leukemia & …, 2017 - Taylor & Francis
Infectious complications are a major cause of morbidity and mortality in indolent
lymphoproliferative disease patients [1]. The pathogenesis of infections is related to both …

Is ibrutinib associated with disseminated cryptococcosis with CNS involvement?

MB Abid, J Stromich, ND Gundacker - Cancer Biology & Therapy, 2019 - Taylor & Francis
Chronic lymphocytic leukemia (CLL) is a disorder of B cells that affects humoral as well as
cell-mediated immunity. Protection against cryptococcal infections is mounted by an intricate …

[PDF][PDF] Concurrent cerebral aspergillosis and abdominal mucormycosis during ibrutinib therapy for chronic lymphocytic leukaemia

A Pouvaret, R Guery, M Montillet, TJ Molina… - Clinical Microbiology …, 2019 - Elsevier
We read with great interest the article from Peri et al. describing a case report of invasive 26
aspergillosis (IA) with primary pulmonary involvement followed by central nervous system 27 …

Cryptococcus neoformans empyema in a patient receiving ibrutinib for diffuse large B-cell lymphoma and a review of the literature

CD Swan, T Gottlieb - Case Reports, 2018 - casereports.bmj.com
We report a case of Cryptococcus neoformans pulmonary infection complicated by
empyema in a 79-year-old man with diffuse large B-cell lymphoma treated with R-CHOP and …

Serious infections in patients receiving ibrutinib for treatment of lymphoid cancer

T Varughese, Y Taur, N Cohen… - Clinical Infectious …, 2018 - academic.oup.com
Abstract Background Ibrutinib is a Bruton tyrosine kinase inhibitor that is used for the
treatment of lymphoid cancers, including chronic lymphocytic leukemia, Waldenström …

Cerebral aspergillosis: An emerging opportunistic infection in patients receiving ibrutinib for chronic lymphocytic leukemia?

E Gaye, A Le Bot, JP Talarmin… - Médecine et …, 2018 - univ-rennes.hal.science
Ibrutinib is a novel oral covalent inhibitor of Bruton's tyrosine kinase (BTK). It has been
approved for the treatment of relapsing chronic lymphocytic leukemia (CLL), or CLL with …