Targeting ferroptosis in acute kidney injury

L Ni, C Yuan, X Wu - Cell Death & Disease, 2022 - nature.com
Acute kidney injury (AKI) is a major public health problem with high incidence and mortality.
As a form of programmed cell death (PCD), ferroptosis could be considered as a process of …

Ferroptosis and acute kidney injury (AKI): molecular mechanisms and therapeutic potentials

Q Feng, X Yu, Y Qiao, S Pan, R Wang… - Frontiers in …, 2022 - frontiersin.org
Acute kidney injury (AKI), a common and serious clinical kidney syndrome with high
incidence and mortality, is caused by multiple pathogenic factors, such as ischemia …

The road from AKI to CKD: molecular mechanisms and therapeutic targets of ferroptosis

R Guo, J Duan, S Pan, F Cheng, Y Qiao, Q Feng… - Cell death & …, 2023 - nature.com
Acute kidney injury (AKI) is a prevalent pathological condition that is characterized by a
precipitous decline in renal function. In recent years, a growing body of studies have …

Emerging role of ferroptosis in acute kidney injury

Z Hu, H Zhang, S Yang, X Wu, D He… - Oxidative medicine …, 2019 - Wiley Online Library
Acute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high
incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are …

The cross‐link between ferroptosis and kidney diseases

J Wang, Y Liu, Y Wang, L Sun - Oxidative Medicine and …, 2021 - Wiley Online Library
Acute and chronic kidney injuries result from structural dysfunction and metabolic disorders
of the kidney in various etiologies, which significantly affect human survival and social …

Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases

J Li, S Zheng, Y Fan, K Tan - Cell Death & Disease, 2023 - nature.com
Kidney diseases remain one of the leading causes of human death and have placed a
heavy burden on the medical system. Regulated cell death contributes to the pathology of a …

Ferroptosis: a potential therapeutic target in acute kidney injury

K Hosohata, T Harnsirikarn… - International Journal of …, 2022 - mdpi.com
Ferroptosis is a recently recognized form of nonapoptotic cell death that is triggered by
reactive oxidative species (ROS) due to iron overload, lipid peroxidation accumulation, or …

The role of ferroptosis in the development of acute and chronic kidney diseases

Y Zhou, J Zhang, Q Guan, X Tao… - Journal of cellular …, 2022 - Wiley Online Library
Ferroptosis, a novel form of regulated cell death, is characterized by imbalance of
intracellular iron and redox systems, resulting from overgeneration of toxic lipid peroxidation …

Abnormal iron and lipid metabolism mediated ferroptosis in kidney diseases and its therapeutic potential

X Zhang, X Li - Metabolites, 2022 - mdpi.com
Ferroptosis is a newly identified form of regulated cell death driven by iron-dependent
phospholipid peroxidation and oxidative stress. Ferroptosis has distinct biological and …

Vitamin K1 inhibits ferroptosis and counteracts a detrimental effect of phenprocoumon in experimental acute kidney injury

B Kolbrink, FA von Samson-Himmelstjerna… - Cellular and Molecular …, 2022 - Springer
Ferroptosis, a type of iron-dependent programmed cell death distinct from apoptosis,
necroptosis, and other types of cell death, is characterized by lipid peroxidation, reactive …