Combination antibiotic therapy for Gram-negative sepsis is controversial. The present review
provides a brief summary of the existing knowledge on combination therapy for severe …

Combination antibiotic therapy for invasive infections with Gram-negative bacteria is
employed in many health care facilities, especially for certain subgroups of patients …

Objective: To assess whether a potential benefit with combination antibiotic therapy is
restricted to the most critically ill subset of patients, particularly those with septic shock. Data …

Widespread emergence of multidrug resistant (MDR) bacterial pathogens is a problem of
global dimension. MDR infections are difficult to treat and frequently associated with high …

There has been little improvement in septic shock mortality in the past 70 years, despite ever
more broad-spectrum and potent antimicrobials. In the past, resuscitative elements have …

Background: Septic shock represents the major cause of infection-associated mortality in the
intensive care unit. The possibility that combination antibiotic therapy of bacterial septic …

The widespread emergence of antibiotic‐resistant gram‐negative organisms has
compromised the utility of current treatment options for severe infections caused by these …

Interactions between antibiotic combinations predicted by in vitro studies are not consistently
reflected in clinical trials. Beta-lactam–aminoglycoside combinations, synergistic in vitro, do …

Whether combination antimicrobial therapy is more efficacious than monotherapy for gram-
negative bacteraemia remains controversial. Although there are theoretical advantages to …

The optimal approach for empirical antibiotic therapy in patients with severe sepsis and
septic shock remains controversial. A retrospective cohort study was conducted in the …