Identification of bioactive metabolites using activity metabolomics

MM Rinschen, J Ivanisevic, M Giera… - Nature reviews Molecular …, 2019 - nature.com
The metabolome, the collection of small-molecule chemical entities involved in metabolism,
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …

Exploring disease through metabolomics

N Vinayavekhin, EA Homan… - ACS chemical biology, 2010 - ACS Publications
Metabolomics approaches provide an analysis of changing metabolite levels in biological
samples. In the past decade, technical advances have spurred the application of …

Metabolomics: beyond biomarkers and towards mechanisms

CH Johnson, J Ivanisevic, G Siuzdak - Nature reviews Molecular cell …, 2016 - nature.com
Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …

Cell metabolomics

A Zhang, H Sun, H Xu, S Qiu, X Wang - Omics: a journal of …, 2013 - liebertpub.com
Metabolomics technologies enable the examination and identification of endogenous
biochemical reaction products, revealing information on the precise metabolic pathways and …

Metabolomics for biomarker discovery: moving to the clinic

A Zhang, H Sun, G Yan, P Wang… - Biomed research …, 2015 - Wiley Online Library
To improve the clinical course of diseases, more accurate diagnostic and assessment
methods are required as early as possible. In order to achieve this, metabolomics offers new …

An overview of metabolomics data analysis: current tools and future perspectives

S Lamichhane, P Sen, AM Dickens… - Comprehensive …, 2018 - Elsevier
Metabolomics is a study of small molecules in the body and the associated metabolic
pathways and is considered to provide a close link between organism's genotype and …

Metabolomics: small molecules that matter more

BC Muthubharathi, T Gowripriya, K Balamurugan - Molecular omics, 2021 - pubs.rsc.org
Metabolomics, an analytical study with high-throughput profiling, helps to understand
interactions within a biological system. Small molecules, called metabolites or metabolomes …

Metabolomics analysis for biomarker discovery: advances and challenges

MS Monteiro, M Carvalho, ML Bastos… - Current medicinal …, 2013 - ingentaconnect.com
Over the last decades there has been a change in biomedical research with the search for
single genes, transcripts, proteins, or metabolites being substituted by the coverage of the …

Guide to metabolomics analysis: a bioinformatics workflow

Y Chen, EM Li, LY Xu - Metabolites, 2022 - mdpi.com
Metabolomics is an emerging field that quantifies numerous metabolites systematically. The
key purpose of metabolomics is to identify the metabolites corresponding to each biological …

Metabolomics toward personalized medicine

M Jacob, AL Lopata, M Dasouki… - Mass spectrometry …, 2019 - Wiley Online Library
Metabolomics, which is the metabolites profiling in biological matrices, is a key tool for
biomarker discovery and personalized medicine and has great potential to elucidate the …