Gene therapy using adeno-associated virus vectors
S Daya, KI Berns - Clinical microbiology reviews, 2008 - Am Soc Microbiol
The unique life cycle of adeno-associated virus (AAV) and its ability to infect both
nondividing and dividing cells with persistent expression have made it an attractive vector …
nondividing and dividing cells with persistent expression have made it an attractive vector …
Adeno-associated virus vectors for gene therapy: more pros than cons?
PE Monahan, RJ Samulski - Molecular medicine today, 2000 - cell.com
Gene therapy vectors based on the adeno-associated virus (AAV) are being developed for a
widening variety of therapeutic applications. Enthusiasm for AAV is due, not only to the …
widening variety of therapeutic applications. Enthusiasm for AAV is due, not only to the …
Adeno-associated virus vectorology, manufacturing, and clinical applications
JC Grieger, RJ Samulski - Methods in enzymology, 2012 - Elsevier
Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. The
benefits of using AAV for gene therapy include long-term gene expression, the inability to …
benefits of using AAV for gene therapy include long-term gene expression, the inability to …
Basic biology of adeno-associated virus (AAV) vectors used in gene therapy
B Balakrishnan, GR Jayandharan - Current gene therapy, 2014 - ingentaconnect.com
Adeno-associated virus (AAV) based vectors have emerged as important tools for gene
therapy in humans. The recent successes seen in Phase I/II clinical trials have also …
therapy in humans. The recent successes seen in Phase I/II clinical trials have also …
Adeno-associated virus vectors in clinical trials
BJ Carter - Human gene therapy, 2005 - liebertpub.com
ADENO-ASSOCIATED VIRUS (AAV) VECTORS were first devel-oped 20 years ago (Carter,
2004) and an AAV vector was first administered to a human subject in November 1995 …
2004) and an AAV vector was first administered to a human subject in November 1995 …
[HTML][HTML] The state of the art of adeno-associated virus-based vectors in gene therapy
RS Coura, NB Nardi - Virology journal, 2007 - Springer
The adeno-associated virus (AAV) has rapidly gained popularity in gene therapy since the
establishment of the first AAV2 infectious clone, in 1982, due to some of their distinguishing …
establishment of the first AAV2 infectious clone, in 1982, due to some of their distinguishing …
AAV-mediated gene therapy for research and therapeutic purposes
RJ Samulski, N Muzyczka - Annual review of virology, 2014 - annualreviews.org
Adeno-associated virus (AAV) is a small, nonenveloped virus that was adapted 30 years
ago for use as a gene transfer vehicle. It is capable of transducing a wide range of species …
ago for use as a gene transfer vehicle. It is capable of transducing a wide range of species …
Adeno-associated virus at 50: a golden anniversary of discovery, research, and gene therapy success—a personal perspective
E Hastie, RJ Samulski - Human gene therapy, 2015 - liebertpub.com
Fifty years after the discovery of adeno-associated virus (AAV) and more than 30 years after
the first gene transfer experiment was conducted, dozens of gene therapy clinical trials are …
the first gene transfer experiment was conducted, dozens of gene therapy clinical trials are …
Production and characterization of adeno-associated viral vectors
JC Grieger, VW Choi, RJ Samulski - Nature protocols, 2006 - nature.com
The adeno-associated virus (AAV) is one of the most promising viral vectors for human gene
therapy. As with any potential therapeutic system, a thorough understanding of it at the in …
therapy. As with any potential therapeutic system, a thorough understanding of it at the in …
Gene therapy progress and prospects: recombinant adeno-associated virus (rAAV) vectors
TR Flotte - Gene therapy, 2004 - nature.com
Recombinant adeno-associated virus (rAAV) vectors are unique among the vector classes
currently available for human gene therapy in that they are based upon a class of viruses …
currently available for human gene therapy in that they are based upon a class of viruses …