Xanthine oxidoreductase (XOR) is the enzyme that catalyzes the oxidation of hypoxanthine
to xanthine and xanthine to uric acid and is widely distributed among species. In addition to …

Human xanthine oxidoreductase (XOR) catalyzes the last two steps of purine catabolism
and is present in two interconvertible forms, which may utilize O2 or NAD+ as electron …

Xanthine oxidase (XO) is a critical source of reactive oxygen species (ROS) in inflammatory
disease. Focus, however, has centered almost exclusively on XO-derived superoxide …

Xanthine oxidoreductase (XOR) is a ubiquitous metalloflavoprotein that appears in two
interconvertible yet functionally distinct forms: xanthine dehydrogenase (XD), which is …

Human xanthine oxidoreductase (XOR) is a multiple-level regulated enzyme, resulting from
a complicated evolutionary process that assigned it many physiological roles. The main …

Obesity and related pathologies such as diabetes and metabolic syndrome are associated
with chronic inflammation and cancer. The serum level of xanthine oxidoreductase (XOR) is …

The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …

In addition to its critical role in purine metabolism, xanthine oxidoreductase (XOR) has been
implicated in the development of tissue oxidative damage in a wide variety of respiratory and …

Hemolytic diseases are associated with elevated levels of circulating free heme that can
mediate endothelial dysfunction directly via redox reactions with biomolecules or indirectly …

A plethora of vascular pathology is associated with inflammation, hypoxia and elevated rates
of reactive species generation. A critical source of these reactive species is the purine …