Small-cell lung cancer: what we know, what we need to know and the path forward

AF Gazdar, PA Bunn, JD Minna - Nature Reviews Cancer, 2017 - nature.com
Small-cell lung cancer (SCLC) is a deadly tumour accounting for approximately 15% of lung
cancers and is pathologically, molecularly, biologically and clinically very different from other …

Advances in small-cell lung cancer (SCLC) translational research

BJ Drapkin, CM Rudin - Cold Spring …, 2021 - perspectivesinmedicine.cshlp.org
Over the past several years, we have witnessed a resurgence of interest in the biology and
therapeutic vulnerabilities of small-cell lung cancer (SCLC). This has been driven in part …

Small cell lung cancer: where do we go from here?

LA Byers, CM Rudin - Cancer, 2015 - Wiley Online Library
Small cell lung cancer (SCLC) is an aggressive disease that accounts for approximately
14% of all lung cancers. In the United States, approximately 31,000 patients are diagnosed …

[HTML][HTML] Small cell lung cancer (SCLC): no treatment advances in recent years

F Koinis, A Kotsakis, V Georgoulias - Translational lung cancer …, 2016 - ncbi.nlm.nih.gov
Small cell lung cancer (SCLC) is an aggressive malignancy with a distinct natural history
and dismal prognosis. Given its predisposition for early dissemination, patients are …

Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions

Z Megyesfalvi, CM Gay, H Popper… - CA: a cancer journal …, 2023 - Wiley Online Library
Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity.
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …

Small cell lung cancer: will recent progress lead to improved outcomes?

MC Pietanza, LA Byers, JD Minna, CM Rudin - Clinical Cancer Research, 2015 - AACR
Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy with a unique
natural history characterized by a short doubling time, high growth fraction, and early …

[HTML][HTML] Small cell lung cancer: can recent advances in biology and molecular biology be translated into improved outcomes?

PA Bunn Jr, JD Minna, A Augustyn, AF Gazdar… - Journal of Thoracic …, 2016 - Elsevier
Small cell lung cancer (SCLC) is one of the four major histological types of lung cancer. The
incidence of SCLC in developed countries has declined in recent years, presumably …

Small-cell lung cancer

CM Rudin, E Brambilla, C Faivre-Finn… - Nature Reviews Disease …, 2021 - nature.com
Small-cell lung cancer (SCLC) represents about 15% of all lung cancers and is marked by
an exceptionally high proliferative rate, strong predilection for early metastasis and poor …

Advances in small cell lung cancer

GP Kalemkerian, BJ Schneider - Hematology/Oncology …, 2017 - hemonc.theclinics.com
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with clinical and
pathologic characteristics distinct from those of non-SCLC. The primary cause of SCLC is …

[HTML][HTML] Small cell lung cancer: novel treatments beyond immunotherapy

JJ Meijer, A Leonetti, G Airò, M Tiseo, C Rolfo… - Seminars in cancer …, 2022 - Elsevier
Small cell lung cancer (SCLC) arises in peribronchial locations and infiltrates the bronchial
submucosa, including about 15% of lung cancer cases. Despite decades of research, the …