Nrf2 overexpression for the protective effect of skin‐derived precursors against UV‐induced damage: evidence from a three‐dimensional skin model
D Xian, X Xiong, J Xu, L Xian, Q Lei… - Oxidative medicine …, 2019 - Wiley Online Library
Background. Skin photodamage is associated with ultraviolet‐(UV‐) induced reactive
oxygen species (ROS) overproduction and nuclear factor erythroid 2‐related factor 2 (Nrf2) …
oxygen species (ROS) overproduction and nuclear factor erythroid 2‐related factor 2 (Nrf2) …
[HTML][HTML] Photoprotection against UV-induced damage by skin-derived precursors in hairless mice
D Xian, X Gao, X Xiong, J Xu, L Yang, L Pan… - … of Photochemistry and …, 2017 - Elsevier
Background Skin photodamage is associated with UV-induced overproduction of reactive
oxygen species (ROS) and the inactivation of NF-E2-related factor 2 (Nrf2). Skin-derived …
oxygen species (ROS) and the inactivation of NF-E2-related factor 2 (Nrf2). Skin-derived …
Acceleration of UVB‐induced photoageing in nrf2 gene‐deficient mice
A Hirota, Y Kawachi, M Yamamoto… - Experimental …, 2011 - Wiley Online Library
Ultraviolet (UV) radiation is one of the most important environmental factors involved in the
pathogenesis of premature skin ageing, termed photoageing. The harmful effects of UV in …
pathogenesis of premature skin ageing, termed photoageing. The harmful effects of UV in …
[HTML][HTML] Attenuation of UVB-induced sunburn reaction and oxidative DNA damage with no alterations in UVB-induced skin carcinogenesis in Nrf2 gene-deficient mice
Y Kawachi, X Xu, S Taguchi, H Sakurai… - Journal of Investigative …, 2008 - Elsevier
UV radiation is an important environmental factor in the pathogenesis of skin aging and
cancer. Many harmful effects of UV radiation are associated with generation of reactive …
cancer. Many harmful effects of UV radiation are associated with generation of reactive …
Amelioration of UVB-induced oxidative stress and inflammation in fat-1 transgenic mouse skin
Abstract ω-3 polyunsaturated fatty acids (PUFAs), which are abundant in fish oils, are known
to scavenge lipid peroxyl radicals and potentiate host immune defence. As UVB-induced …
to scavenge lipid peroxyl radicals and potentiate host immune defence. As UVB-induced …
Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis
M Schäfer, S Dütsch, U auf dem Keller… - Genes & …, 2010 - genesdev.cshlp.org
Ultraviolet (UV) B irradiation can severely damage the skin and even induce tumorigenesis.
It exerts its effects by direct DNA modification and by formation of reactive oxygen species …
It exerts its effects by direct DNA modification and by formation of reactive oxygen species …
[HTML][HTML] Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages
Nrf2 plays a critical role in defending against oxidative stress and inflammation. We
previously reported that Nrf2 confers protection against ultraviolet-B (UVB)-induced …
previously reported that Nrf2 confers protection against ultraviolet-B (UVB)-induced …
Impact of Nrf2 on UVB‐induced skin inflammation/photoprotection and photoprotective effect of sulforaphane
CL Saw, MT Huang, Y Liu, TO Khor… - Molecular …, 2011 - Wiley Online Library
Ultraviolet (UV) of sunlight is a complete carcinogen that can burn skin, enhance
inflammation, and drive skin carcinogenesis. Previously, we have shown that sulforaphane …
inflammation, and drive skin carcinogenesis. Previously, we have shown that sulforaphane …
[HTML][HTML] Identification of UV-protective activators of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) by combining a chemical library screen with computer …
F Lieder, F Reisen, T Geppert, G Sollberger… - Journal of Biological …, 2012 - ASBMB
Nuclear factor erythroid-derived 2-related factor 2 (Nrf2) is a master regulator of cellular
antioxidant defense systems, and activation of this transcription factor is a promising strategy …
antioxidant defense systems, and activation of this transcription factor is a promising strategy …
Skin‐derived precursors against UVB‐induced apoptosis via Bcl‐2 and Nrf2 upregulation
J Zhong, L Li - BioMed Research International, 2016 - Wiley Online Library
Bcl‐2 and Nrf2 are critical factors in protecting cells against UVB‐induced apoptosis. Hair‐
follicle‐bulge stem cells could resist ionization through Bcl‐2 upregulation. Skin‐derived …
follicle‐bulge stem cells could resist ionization through Bcl‐2 upregulation. Skin‐derived …