An intermediate-effect size variant in UMOD confers risk for chronic kidney disease
The kidney-specific gene UMOD encodes for uromodulin, the most abundant protein
excreted in normal urine. Rare large-effect variants in UMOD cause autosomal dominant …
excreted in normal urine. Rare large-effect variants in UMOD cause autosomal dominant …
[HTML][HTML] Association of Estimated Glomerular Filtration Rate and Urinary Uromodulin Concentrations with Rare Variants Identified by UMOD Gene Region …
A Köttgen, Q Yang, LC Shimmin, A Tin, C Schaeffer… - PloS one, 2012 - journals.plos.org
Background Recent genome-wide association studies (GWAS) have identified common
variants in the UMOD region associated with kidney function and disease in the general …
variants in the UMOD region associated with kidney function and disease in the general …
The UMOD locus: insights into the pathogenesis and prognosis of kidney disease
O Devuyst, C Pattaro - Journal of the American Society of …, 2018 - journals.lww.com
The identification of genetic factors associated with kidney disease has the potential to
provide critical insights into disease mechanisms. Genome-wide association studies have …
provide critical insights into disease mechanisms. Genome-wide association studies have …
Uromodulin: from monogenic to multifactorial diseases
F Scolari, C Izzi, GM Ghiggeri - Nephrology Dialysis …, 2015 - academic.oup.com
Uromodulin, the major protein secreted in normal urine, is exclusively produced in the thick
ascending limb (TAL) cells of the kidney. The exact role uromodulin (UMOD) plays in renal …
ascending limb (TAL) cells of the kidney. The exact role uromodulin (UMOD) plays in renal …
Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis
M Olden, T Corre, C Hayward, D Toniolo… - Journal of the …, 2014 - journals.lww.com
Uromodulin is expressed exclusively in the thick ascending limb and is the most abundant
protein excreted in normal urine. Variants in UMOD, which encodes uromodulin, are …
protein excreted in normal urine. Variants in UMOD, which encodes uromodulin, are …
[HTML][HTML] UMOD as a susceptibility gene for end-stage renal disease
A Reznichenko, CA Böger, H Snieder… - BMC medical …, 2012 - Springer
Background In recent genetic association studies, common variants including rs12917707 in
the UMOD locus have shown strong evidence of association with eGFR, prevalent and …
the UMOD locus have shown strong evidence of association with eGFR, prevalent and …
[HTML][HTML] UMOD and the architecture of kidney disease
The identification of genetic factors associated with the risk, onset, and progression of kidney
disease has the potential to provide mechanistic insights and therapeutic perspectives. In …
disease has the potential to provide mechanistic insights and therapeutic perspectives. In …
Mendelian randomization to assess causality between uromodulin, blood pressure and chronic kidney disease
UMOD variants associated with higher levels of urinary uromodulin (uUMOD) increase the
risk of chronic kidney disease (CKD) and hypertension. However, uUMOD levels also reflect …
risk of chronic kidney disease (CKD) and hypertension. However, uUMOD levels also reflect …
[HTML][HTML] Association of Variants at UMOD with Chronic Kidney Disease and Kidney Stones—Role of Age and Comorbid Diseases
Chronic kidney disease (CKD) is a worldwide public health problem that is associated with
substantial morbidity and mortality. To search for sequence variants that associate with CKD …
substantial morbidity and mortality. To search for sequence variants that associate with CKD …
Uromodulin levels associate with a common UMOD variant and risk for incident CKD
A Köttgen, SJ Hwang, MG Larson… - Journal of the …, 2010 - journals.lww.com
Common variants in the region of the UMOD gene, which encodes uromodulin (Tamm-
Horsfall protein), associate with chronic kidney disease (CKD) and estimated GFR (eGFR) …
Horsfall protein), associate with chronic kidney disease (CKD) and estimated GFR (eGFR) …