Purpose Inadequate piperacillin (PIP) exposure in intensive care unit (ICU) patients
threatens therapeutic success. Model-informed precision dosing (MIPD) might be promising …

Background Beta-lactam antimicrobial concentrations are frequently suboptimal in critically
ill patients. Population pharmacokinetic (PopPK) modeling is the golden standard to predict …

Piperacillin-tazobactam is frequently used for empirical and targeted therapy of infections in
critically ill patients. Considerable pharmacokinetic (PK) variability is observed in critically ill …

Background: Modeling and simulation is increasingly used to study pediatric
pharmacokinetics, but clinical implementation of age-appropriate doses lags behind …

Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-
lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models …

Therapeutic drug monitoring (TDM) of antibiotics is recommended and increasingly used in
critically ill patients to optimize target attainment and account for interpatient …

Optimization of antibiotic dosing is a treatment intervention that is likely to improve outcomes
in severe infections. The aim of this retrospective study was to describe the therapeutic …

Purpose Individualising drug dosing using model-informed precision dosing (MIPD) of beta-
lactam antibiotics and ciprofloxacin has been proposed as an alternative to standard dosing …

The objectives of this study were (i) to compare the plasma concentration–time profiles for
first-dose and steady-state piperacillin administered by intermittent or continuous dosing to …

Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on
individualized dosage optimization, integrating complex mathematical and statistical models …