The Mechanisms of Regulated Cell Death: Structural and Functional Proteomic Pathways Induced or Inhibited by a Specific Protein—A Narrative Review

D Fernández-Lázaro, B Sanz, J Seco-Calvo - Proteomes, 2024 - mdpi.com
Billions of cells die in us every hour, and our tissues do not shrink because there is a natural
regulation where Cell Death (CD) is balanced with cell division. The process in which cells …

Mechanisms of Programmed Cell Death: Structural and Functional Proteomic-Pathways. A Narrative Review.

D Fernández-Lázaro, B Sanz, J Seco-Calvo - 2023 - preprints.org
Apoptosis, necroptosis, and autophagy are cellular mechanisms by which cells are
programmed to die under a wide range of physiological and developmental stimuli. A …

Transcriptional control of the core cell-death machinery

S Kumar, D Cakouros - Trends in biochemical sciences, 2004 - cell.com
Developmental and physiological cues, as well as signals in response to cell damage,
initiate a cell suicide program that is often referred to as apoptosis or programmed cell death …

[HTML][HTML] Insights into programmed cell death through structural biology

SW Fesik - Cell, 2000 - cell.com
Programmed cell death plays a critical role in controlling the number of cells in development
and throughout an organism's life by the removal of cells at the appropriate time. It is an …

Cellular demolition: Proteins as molecular players of programmed cell death

YK Dhuriya, D Sharma, AA Naik - International journal of biological …, 2019 - Elsevier
Apoptosis, a well-characterized and regulated cell death programme in eukaryotes plays a
fundamental role in developing or later-life periods to dispose of unwanted cells to maintain …

Cell death proteins: an evolutionary role in cellular adaptation before the advent of apoptosis

SA Dick, LA Megeney - Bioessays, 2013 - Wiley Online Library
Programmed cell death (PCD) or apoptosis is a broadly conserved phenomenon in
metazoans, whereby activation of canonical signal pathways induces an ordered …

Caspase-independent cell death

M Leist, M Jäättelä - 2002 - kops.uni-konstanz.de
Caspase-mediated apoptosis is the death program of choice in many developmental and
physiologic settings. It would, however, be very dangerous for the organism to depend on a …

Mechanisms of apoptosis

JC Reed - The American journal of pathology, 2000 - Elsevier
Programmed cell death plays critical roles in a wide variety of physiological processes
during fetal development and in adult tissues. In most cases, physiological cell death occurs …

CDPs: caspase-dependent non-lethal cellular processes

L Aram, K Yacobi-Sharon, E Arama - Cell Death & Differentiation, 2017 - nature.com
A key discovery in the field of programmed cell death (PCD) is the realization that apoptosis,
the most abundant form of PCD in metazoa, is executed by an evolutionary conserved family …

From caspases to alternative cell-death mechanisms

M Jäättelä, M Leist - Essentials of apoptosis: a guide for basic and clinical …, 2003 - Springer
Programmed cell death (PCD) is essential for the development and maintenance of
multicellular organisms. Many eukaryotic cells that die and are removed in a programmed …