Although pain reduction is commonly the primary outcome in chronic pain clinical trials,
physical functioning is also important. A challenge in designing chronic pain trials to …

Two of the most difficult problems in evaluating treatment efficacy in pain research involve
what constitutes a ''successful''outcome and how best to measure it (Turk et al., 2003) …

Many patients with chronic pain do not obtain adequate relief or experience unacceptable
side effects from existing treatments. Moreover, even when clinical trials report positive …

A consensus meeting was convened by the Initiative on Methods, Measurement, and Pain
Assessment in Clinical Trials (IMMPACT) to provide recommendations for interpreting …

This two-phase study was conducted to identify relevant domains of patient-reported
outcomes from the perspective of people who experience chronic pain. In Phase 1, focus …

Clinical outcome assessments (COAs) measure outcomes that are meaningful to patients in
clinical trials and are critical for determining whether a treatment is effective. The objectives …

Objective. To provide recommendations for the core outcome domains that should be
considered by investigators conducting clinical trials of the efficacy and effectiveness of …

Objective Chronic musculoskeletal pain (CMSP) disorders are among the most prevalent
and disabling conditions worldwide. It would be advantageous to have common outcome …

Valid and reliable assessment of pain is fundamental for both clinical trials and effective pain
management. The nature of pain makes objective measurement impossible. Chronic …

Objective:: The goal of this analysis is a better understanding of the issues involved in
establishing the amount of change in pain that must be reported by subjects, participating in …