Decrypting the potential role of α-lipoic acid in Alzheimer's disease

D Kaur, T Behl, A Sehgal, S Singh, N Sharma… - Life Sciences, 2021 - Elsevier
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases with
motor disturbances, cognitive decline, and behavioral impairment. It is characterized by the …

Potential therapeutic effects of lipoic acid on memory deficits related to aging and neurodegeneration

P Molz, N Schröder - Frontiers in pharmacology, 2017 - frontiersin.org
The aging process comprises a series of organic alterations, affecting multiple systems,
including the nervous system. Aging has been considered the main risk factor for the …

Mitochondrial Dysfunction and Alpha‐Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?

SM Dos Santos, CFR Romeiro… - Oxidative medicine …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disorder characterised by impairments in
the cognitive domains associated with orientation, recording, and memory. This pathology …

[HTML][HTML] α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

YH Zhang, DW Wang, SF Xu, S Zhang, YG Fan… - Redox Biology, 2018 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disease and is
characterized by neurofibrillary tangles (NFTs) composed of Tau protein. α-Lipoic acid (LA) …

Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease

A Maczurek, K Hager, M Kenklies, M Sharman… - Advanced drug delivery …, 2008 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient
memory and cognition, communication ability with the social environment and the ability to …

Chronic dietary α-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice

JF Quinn, JR Bussiere, RS Hammond, TJ Montine… - Neurobiology of …, 2007 - Elsevier
Oxidative stress may play a key role in Alzheimer's disease (AD) neuropathology. Here, the
effects of the antioxidant, α-lipoic acid (ALA) were tested on the Tg2576 mouse, a transgenic …

Effect of alpha-lipoic acid on memory, oxidation, and lifespan in SAMP8 mice

SA Farr, TO Price, WA Banks, N Ercal… - Journal of Alzheimer's …, 2012 - content.iospress.com
Oxidative damage is associated with neurodegenerative disorders such as Alzheimer's
disease (AD). The antioxidant alpha-lipoic acid has been found to improve memory in …

Protection against amyloid beta peptide and iron/hydrogen peroxide toxicity by alpha lipoic acid

MA Lovell, C Xie, S Xiong… - Journal of Alzheimer's …, 2003 - content.iospress.com
Current evidence supports the role of oxidative stress in the pathogenesis of neuron
degeneration in Alzheimer's disease (AD). α-Lipoic acid (LA), an essential cofactor in …

α-Lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway

L Zhang, G qaing Xing, JL Barker, Y Chang, D Maric… - Neuroscience …, 2001 - Elsevier
Substantial evidence suggests that the accumulation of β-amyloid (Aβ)-derived peptides
contributes to the aetiology of Alzheimer's disease (AD) by stimulating formation of free …

Lipoic acid as a novel treatment for Alzheimer's disease and related dementias

L Holmquist, G Stuchbury, K Berbaum, S Muscat… - Pharmacology & …, 2007 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient
memory and cognition, communication ability with the social environment and the ability to …