Ultraslow thrombolytic therapy: a novel strategy in the management of PROsthetic MEchanical valve Thrombosis and the prEdictors of outcomE: the Ultra-slow …

M Özkan, S Gündüz, OM Gürsoy, S Karakoyun… - American heart …, 2015 - Elsevier
Background Low-dose (25 mg), slow infusion (6 hours) of tissue-type plasminogen activator
(t-PA) with repetition as needed has been shown to provide effective and safer thrombolysis …

Diagnosis, treatment & management of prosthetic valve thrombosis: the key considerations

S Gündüz, M Kalçık, MO Gürsoy, A Güner… - Expert Review of …, 2020 - Taylor & Francis
Introduction: Prosthetic heart valve thrombosis is a life-threatening complication after valve
replacement surgery. Although subtherapeutic anticoagulation is the main cause, there are …

Comparison of different TEE-guided thrombolytic regimens for prosthetic valve thrombosis: the TROIA trial

M Özkan, S Gündüz, M Biteker, MA Astarcioglu… - JACC: Cardiovascular …, 2013 - jacc.org
Objectives: The aim of this prospective study was to identify the most effective and safest
regimen among different thrombolytic treatment strategies. Background: The best treatment …

Thrombolysis or surgery in patients with obstructive mechanical valve thrombosis: the multicenter HATTUSHA study

M Özkan, S Gündüz, A Güner, M Kalçık… - Journal of the American …, 2022 - jacc.org
Background Prosthetic valve thrombosis (PVT) is one of the life-threatening complications of
prosthetic heart valve replacement. Due to the lack of randomized controlled trials, the …

Intravenous thrombolytic treatment of mechanical prosthetic valve thrombosis: a study using serial transesophageal echocardiography

M Özkan, C Kaymaz, C Kirma, K Sönmez… - Journal of the American …, 2000 - jacc.org
OBJECTIVE We analyzed the results of intravenous thrombolytic treatment under
transesophageal echocardiographic (TEE) guidance in prosthetic valve thrombosis …

Thrombolytic therapy for prosthetic valve thrombosis: short-and long-term results

D Gupta, SS Kothari, VK Bahl, KC Goswami… - American heart …, 2000 - Elsevier
Background Thrombolytic therapy (TT) has evolved as an alternative to surgery for prosthetic
valve thrombosis (PVT), but its utility in patient management is still debated and the long …

Accelerated infusion of streptokinase for the treatment of left-sided prosthetic valve thrombosis: a randomized controlled trial

G Karthikeyan, RS Math, N Mathew, B Shankar… - Circulation, 2009 - Am Heart Assoc
Background—No large prospective studies have evaluated the efficacy of fibrinolytic therapy
for left-sided prosthetic valve thrombosis, yet it remains the first line of treatment in …

[HTML][HTML] Treatment of prosthetic valve thrombosis: current evidence and future directions

M Biteker, I Altun, O Basaran, V Dogan… - Journal of clinical …, 2015 - ncbi.nlm.nih.gov
Prosthetic heart valve thrombosis (PVT) is a rare but serious complication with high
morbidity and mortality. The optimal treatment of the PVT is controversial and depends on …

Management of prosthetic valve thrombosis.

M Lengyel - The Journal of Heart Valve Disease, 2004 - europepmc.org
Prosthetic valve thrombosis (PVT) is a life-threatening disease, the treatment strategies for
which remain controversial. Transesophageal echocardiography (TEE) is the diagnostic …

Comparison of thrombolysis versus surgery as a first line therapy for prosthetic heart valve thrombosis

S Keuleers, P Herijgers, MC Herregods, W Budts… - The American journal of …, 2011 - Elsevier
Prosthetic valve thrombosis (PVT) is one of the most serious long-term complications after
heart valve replacement, and optimal treatment remains unclear. The investigators report …