Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling

RA Coleman, DG Mashek - Chemical reviews, 2011 - ACS Publications
Triacylglycerol (TAG) is the primary unit of energy storage in eukaryotic cells. TAG comprises
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …

Regulation and function of triacylglycerol lipases in cellular metabolism

MJ Watt, GR Steinberg - Biochemical Journal, 2008 - portlandpress.com
The ability to store energy in the form of energy-dense TAG (triacylglycerol) and to mobilize
these stores rapidly during times of low carbohydrate availability (fasting or famine) or during …

[HTML][HTML] Triacylglycerol metabolism in adipose tissue

M Ahmadian, RE Duncan, K Jaworski… - Future …, 2007 - ncbi.nlm.nih.gov
Triacylglycerol (TAG) in adipose tissue serves as the major energy storage form in higher
eukaryotes. Obesity, resulting from excess white adipose tissue, has increased dramatically …

Physiological and nutritional regulation of enzymes of triacylglycerol synthesis

RA Coleman, TM Lewin, DM Muoio - Annual review of nutrition, 2000 - annualreviews.org
Although triacylglycerol stores play the critical role in an organism's ability to withstand fuel
deprivation and are strongly associated with such disorders as diabetes, obesity, and …

Enzymes of triacylglycerol synthesis and their regulation

RA Coleman, DP Lee - Progress in lipid research, 2004 - Elsevier
Since the pathways of glycerolipid biosynthesis were elucidated in the 1950's, considerable
knowledge has been gained about the enzymes that catalyze the lipid biosynthetic reactions …

[HTML][HTML] Lipolysis–a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

A Lass, R Zimmermann, M Oberer, R Zechner - Progress in lipid research, 2011 - Elsevier
Lipolysis is the biochemical pathway responsible for the catabolism of triacylglycerol (TAG)
stored in cellular lipid droplets. The hydrolytic cleavage of TAG generates non-esterified fatty …

Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolism

CLE Yen, DW Nelson, MI Yen - Journal of lipid research, 2015 - ASBMB
The intestine plays a prominent role in the biosynthesis of triacylglycerol (triglyceride; TAG).
Digested dietary TAG is repackaged in the intestine to form the hydrophobic core of …

Triacylglycerol homeostasis: insights from yeast

SD Kohlwein - Journal of Biological Chemistry, 2010 - ASBMB
The endemic increase in lipid-associated disorders such as obesity and type 2 diabetes
mellitus has placed triacylglycerol metabolism and its associated organelle, lipid droplets, in …

How lipid droplets “TAG” along: Glycerolipid synthetic enzymes and lipid storage

H Wang, MV Airola, K Reue - … et Biophysica Acta (BBA)-Molecular and Cell …, 2017 - Elsevier
Triacylglycerols (TAG) serve as the predominant form of energy storage in mammalian cells,
and TAG synthesis influences conditions such as obesity, fatty liver, and insulin resistance …

[HTML][HTML] The Drosophila model to interrogate triacylglycerol biology

C Heier, S Klishch, O Stilbytska, U Semaniuk… - … et Biophysica Acta (BBA …, 2021 - Elsevier
The deposition of storage fat in the form of triacylglycerol (TAG) is an evolutionarily
conserved strategy to cope with fluctuations in energy availability and metabolic stress …