Gastric cancer is the second leading cause of cancer-related death worldwide, but the
details of gastric carcinogenesis remain unclear. In humans, two preneoplastic metaplasias …

Gastric carcinogenesis involves the loss of parietal cells (oxyntic atrophy) and subsequent
replacement of the normal gastric lineages with metaplastic cells. In humans, two …

Gastric adenocarcinoma of the intestinal type is believed to develop through a series of
histopathologic stages, originally described by Correa, 1 that include chronic gastritis …

Spasmolytic polypeptide-expressing metaplasia (SPEM) develops in patients with chronic
atrophic gastritis due to infection with Helicobacter pylori; it might be a precursor to intestinal …

Objectives Spasmolytic polypeptide-expressing metaplasia (SPEM) develops as a
preneoplastic lesion in the stomachs of mice and humans after parietal cell loss. To identify …

BACKGROUND & AIMS: Gastric cancer evolves in the setting of a pathologic mucosal milieu
characterized by both loss of acid-secreting parietal cells and mucous cell metaplasias …

Objective Spasmolytic polypeptide-expressing metaplasia (SPEM) is a regenerative lesion
in the gastric mucosa and is a potential precursor to intestinal metaplasia/gastric …

Background & Aims In patients with chronic Helicobacter pylori (H pylori) infection, parietal
and chief cell atrophy in the gastric corpus, a process known as spasmolytic polypeptide …

Background & Aims: The emergence of oxyntic atrophy and metaplastic cell lineages in
response to chronic Helicobacter pylori infection predisposes to gastric neoplasia. We have …

Background & Aims: Loss of gastric parietal cells is a critical precursor to gastric metaplasia
and neoplasia. However, the origin of metaplasia remains obscure. Acute parietal cell loss …