[HTML][HTML] Unanswered questions in the regulation and function of the duplicated α7 nicotinic receptor gene CHRFAM7A
S Leonard, R Benfante - Pharmacological Research, 2023 - Elsevier
The α7 nicotinic receptor (α7 nAChR) is an important entry point for Ca 2+ into the cell,
which has broad and important effects on gene expression and function. The gene …
which has broad and important effects on gene expression and function. The gene …
The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function
ML Sinkus, S Graw, R Freedman, RG Ross… - …, 2015 - Elsevier
The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is ubiquitously
expressed in both the central nervous system and in the periphery. CHRNA7 is genetically …
expressed in both the central nervous system and in the periphery. CHRNA7 is genetically …
The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7* nAChR function
T Araud, S Graw, R Berger, M Lee, E Neveu… - Biochemical …, 2011 - Elsevier
The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is a candidate
gene for schizophrenia and an important drug target for cognitive deficits in the disorder …
gene for schizophrenia and an important drug target for cognitive deficits in the disorder …
[HTML][HTML] iPSC model of CHRFAM7A effect on α7 nicotinic acetylcholine receptor function in the human context
The α7 nicotinic acetylcholine receptor (α7nAChR) has been a promising target for diseases
affecting cognition and higher cortical functions; however, the effect observed in animal …
affecting cognition and higher cortical functions; however, the effect observed in animal …
[HTML][HTML] The human-restricted isoform of the α7 nAChR, CHRFAM7A: a double-edged sword in neurological and inflammatory disorders
S Di Lascio, D Fornasari, R Benfante - International Journal of Molecular …, 2022 - mdpi.com
CHRFAM7A is a relatively recent and exclusively human gene arising from the partial
duplication of exons 5 to 10 of the α7 neuronal nicotinic acetylcholine receptor subunit (α7 …
duplication of exons 5 to 10 of the α7 neuronal nicotinic acetylcholine receptor subunit (α7 …
The emergence of the uniquely human α7 nicotinic acetylcholine receptor gene and its roles in inflammation
W Peng, L Mao, X Dang - Gene, 2022 - Elsevier
The uniquely human CHRFAM7A gene is evolved from the fusion of two partially duplicated
genes, ULK4 and CHRNA7. Transcription of CHRFAM7A gene produces a 1256-bp open …
genes, ULK4 and CHRNA7. Transcription of CHRFAM7A gene produces a 1256-bp open …
[HTML][HTML] Translational implications of CHRFAM7A, an elusive human-restricted fusion gene
Genes restricted to humans may contribute to human-specific traits and provide a different
context for diseases. CHRFAM7A is a uniquely human fusion gene and a negative regulator …
context for diseases. CHRFAM7A is a uniquely human fusion gene and a negative regulator …
CHRFAM7A alters binding to the neuronal alpha-7 nicotinic acetylcholine receptor
Introduction CHRFAM7A is a uniquely-human gene that encodes a human-specific variant
of the alpha-7 nicotinic acetylcholine receptor (α7nAchR). While the homopentameric …
of the alpha-7 nicotinic acetylcholine receptor (α7nAchR). While the homopentameric …
[HTML][HTML] A Human-Specific α7-Nicotinic Acetylcholine Receptor Gene in Human Leukocytes: Identification, Regulation and the Consequences of CHRFAM7A …
TW Costantini, X Dang, MV Yurchyshyna, R Coimbra… - Molecular …, 2015 - Springer
The human genome contains a variant form of the α7-nicotinic acetylcholine receptor
(α7nAChR) gene that is uniquely human. This CHRFAM7A gene arose during human …
(α7nAChR) gene that is uniquely human. This CHRFAM7A gene arose during human …
[HTML][HTML] Function of partially duplicated human α7 nicotinic receptor subunit CHRFAM7A gene: Potential implications for the cholinergic anti-inflammatory response
AM de Lucas-Cerrillo, MC Maldifassi, F Arnalich… - Journal of Biological …, 2011 - ASBMB
The neuronal α7 nicotinic receptor subunit gene (CHRNA7) is partially duplicated in the
human genome forming a hybrid gene (CHRFAM7A) with the novel FAM7A gene. The …
human genome forming a hybrid gene (CHRFAM7A) with the novel FAM7A gene. The …