Muscle precursor cells known as myoblasts are essential for muscle development and
regeneration. Notch signaling is an ancient intercellular communication mechanism that …

Notch signaling is critical for skeletal muscle development and regeneration, permitting the
expansion of progenitor cells by preventing premature differentiation. We have interrogated …

Cell-cell interactions mediated by Notch are critical for the maintenance of skeletal muscle
stem cells. However, dynamics, cellular source and identity of functional Notch ligands …

Myogenic stem cells are a promising avenue for the treatment of muscular disorders. Freshly
isolated muscle stem cells have a remarkable engraftment ability in vivo, but their cell …

Skeletal myogenesis involves sequential activation, proliferation, self-renewal/differentiation
and fusion of myogenic stem cells (satellite cells). Notch signaling is known to be essential …

Notch signalling acts in virtually every tissue during the lifetime of metazoans. Recent
studies have pointed to multiple roles for Notch in stem cells during quiescence …

Notch signaling is a conserved cell fate regulator during development and postnatal tissue
regeneration. Using skeletal muscle satellite cells as a model and through myogenic cell …

The Notch signaling pathway plays a crucial role in specifying cellular fates by interaction
between cellular neighbors; however, the molecular mechanism underlying smooth muscle …

The balance between proliferation and differentiation of muscle stem cells is tightly
controlled, ensuring the maintenance of a cellular pool needed for muscle growth and …

Notch signaling is essential to maintain skeletal muscle stem cells in quiescence. However,
the precise roles of different Notch receptors are incompletely defined. Here, we …