Movement and regular physical activity are two important factors that help the human body
prevent, reduce and treat different chronic diseases such as obesity, type 2 diabetes, heart …

Habitual endurance exercise training is associated with multisystemic metabolic adaptations
that lower the risk of inactivity-associated disorders such as obesity and type 2 diabetes …

Cell-derived membrane vesicles (CMVs) are endogenous carriers transporting proteins and
nucleic acids between cells. They appear to play an important role in many disease …

Regular exercise has a central role in human health by reducing the risk of type 2 diabetes,
obesity, stroke and cancer. How exercise is able to promote such systemic benefits has …

Conspectus Extracellular vesicles are nanoparticles produced by cells. They are composed
of cellular membrane with associated membrane proteins that surrounds an aqueous core …

Skeletal muscles secrete various factors, such as proteins/peptides, nucleotides, and
metabolites, which are referred to as myokines. Many of these factors are transported into …

Exercise activates a plethora of metabolic and signalling pathways in skeletal muscle and
other organs causing numerous systemic beneficial metabolic effects. Thus, regular exercise …

Background: The concept of the muscle as a secretory organ, developed during the last
decades, partially answers to the issue of how the crosstalk between skeletal muscle and …

Extracellular vesicles (EVs) are 50–300 nm vesicles secreted by eukaryotic cells. They can
carry cargo (including miRNA) from the donor cell to the recipient cell. miRNAs in EVs can …

Skeletal muscle is a highly vascularized tissue that can secrete proteins called myokines.
These muscle-secreted factors exert biological functions in muscle itself (autocrine effect) or …