[HTML][HTML] Antigen-specific activation and cytokine-facilitated expansion of naive, human CD8+ T cells
M Wölfl, PD Greenberg - Nature protocols, 2014 - nature.com
Antigen-specific priming of human, naive T cells has been difficult to assess. Owing to the
low initial frequency in the naive cell pool of specific T cell precursors, such an analysis has …
low initial frequency in the naive cell pool of specific T cell precursors, such an analysis has …
Optimization of a dendritic cell-based assay for the in vitro priming of naive human CD4+ T cells
JM Moser, ER Sassano, DC Leistritz… - Journal of …, 2010 - Elsevier
Methods to prime human CD4+ T cells in vitro would be of significant value for the pre-
clinical evaluation of vaccine candidates and other immunotherapeutics. However, to date …
clinical evaluation of vaccine candidates and other immunotherapeutics. However, to date …
Human T lymphocyte priming in vitro by haptenated autologous dendritic cells
T Rustemeyer, S De Ligter… - Clinical & …, 1999 - academic.oup.com
Dendritic cells (DC), generated from adherent peripheral blood mononuclear cells (PBMC)
by culturing with granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-4 …
by culturing with granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-4 …
Dynamic programming of CD8+ T lymphocyte responses
MJB van Stipdonk, G Hardenberg, MS Bijker… - Nature …, 2003 - nature.com
The initial encounter with an antigen-presenting cell (APC) is the primary force behind the
expansion, differentiation and survival of naive T cells. Using an APC that permits temporal …
expansion, differentiation and survival of naive T cells. Using an APC that permits temporal …
Rapid development of T cell memory
Prime-boost immunization is a promising strategy for inducing and amplifying pathogen-or
tumor-specific memory CD8 T cell responses. Although expansion of CD8 T cell populations …
tumor-specific memory CD8 T cell responses. Although expansion of CD8 T cell populations …
Efficient priming of protein antigen–specific human CD4+ T cells by monocyte-derived dendritic cells
K Schlienger, N Craighead, KP Lee… - Blood, The Journal …, 2000 - ashpublications.org
Dendritic cells (DCs) have the unique ability to initiate an immune response in vivo by
capturing antigens (Ags) in peripheral tissues and migrating to secondary lymphoid organs …
capturing antigens (Ags) in peripheral tissues and migrating to secondary lymphoid organs …
Cross-priming
MJ Bevan - Nature immunology, 2006 - nature.com
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CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
EM Janssen, EE Lemmens, T Wolfe, U Christen… - Nature, 2003 - nature.com
A long-standing paradox in cellular immunology concerns the conditional requirement for
CD4+ T-helper (TH) cells in the priming of cytotoxic CD8+ T lymphocyte (CTL) responses in …
CD4+ T-helper (TH) cells in the priming of cytotoxic CD8+ T lymphocyte (CTL) responses in …
Enumeration of human antigen–specific naive CD8+ T cells reveals conserved precursor frequencies
C Alanio, F Lemaitre, HKW Law… - Blood, The Journal …, 2010 - ashpublications.org
The number of antigen-specific naive CD8+ T cells is believed to be important in the shaping
of adaptive immune responses, and is predictive for the magnitude of priming responses in …
of adaptive immune responses, and is predictive for the magnitude of priming responses in …
Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells
MA Williams, AJ Tyznik, MJ Bevan - Nature, 2006 - nature.com
Abstract Although interleukin-2 (IL-2) was initially characterized as the primary T-cell growth
factor following in vitro activation, less is known about its role in shaping T-cell responses to …
factor following in vitro activation, less is known about its role in shaping T-cell responses to …