The limited bioavailability of plant-derived natural products with anticancer activity poses
major challenges to the pharmaceutical industry. An example of this is camptothecin, a …

Camptothecin is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza
pumila is an ideal plant model for the study of camptothecin production, with various …

Camptothecin (CPT) has unique anti-tumor activities, and its analogs such as irinotecan and
topotecan are clinically used as anti-cancer drugs. Recently, CPT biosynthesis pathway is …

The plant Ophiorrhiza pumila produces camptothecin (CPT), a kind of terpene indole
alkaloid (TIAs) that has been widely used in treatment of cancer. Tryptophan-arginine-lysine …

Camptothecin is a plant-derived alkaloid and important precursor of clinically used anti-
tumor drugs, but little is known about regulatory mechanism of camptothecin production in …

Camptothecin (CPT) is an anticancer pentacyclic quinoline alkaloid widely used to treat
cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation …

Camptothecin is a monoterpenoid indole alkaloid that exhibits anti-tumor activity. In
Ophiorrhiza pumila, production of camptothecin and its related alkaloids was high in the …

Abstract The Rubiaceae species, Ophiorrhiza pumila, accumulates camptothecin, an anti-
cancer alkaloid with a potent DNA topoisomerase I inhibitory activity, as well as …

Camptothecin derivatives are clinically used anti-tumor compounds that biogenetically
belong to a group of monoterpenoid indole alkaloids (TIA). We have already established a …

Camptothecin (CPT) is a natural compound with remarkable antitumor activities due to its
special mechanism of inhibiting DNA topoisomerase I. Ophiorrhiza pumila was found to …