[HTML][HTML] Tirzepatide once weekly for the treatment of obesity

AM Jastreboff, LJ Aronne, NN Ahmad… - … England Journal of …, 2022 - Mass Medical Soc
Background Obesity is a chronic disease that results in substantial global morbidity and
mortality. The efficacy and safety of tirzepatide, a novel glucose-dependent insulinotropic …

Tirzepatide for the treatment of obesity: rationale and design of the SURMOUNT clinical development program

CW le Roux, S Zhang, LJ Aronne, RF Kushner… - …, 2023 - Wiley Online Library
Objective Obesity is a growing global concern compounded by limited availability of effective
treatment options. The SURMOUNT development program aims to evaluate the efficacy and …

Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity: the SURMOUNT-4 randomized clinical trial

LJ Aronne, N Sattar, DB Horn, HE Bays, S Wharton… - JAMA, 2024 - jamanetwork.com
Importance The effect of continued treatment with tirzepatide on maintaining initial weight
reduction is unknown. Objective To assess the effect of tirzepatide, with diet and physical …

Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis

B Tan, XH Pan, HSJ Chew, RSJ Goh, C Lin… - International Journal of …, 2023 - nature.com
Background Recent studies suggest that tirzepatide, a dual glucose-dependent
insulinotropic-peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA), has …

Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled …

WT Garvey, JP Frias, AM Jastreboff, CW le Roux… - The Lancet, 2023 - thelancet.com
Background Weight reduction is essential for improving health outcomes in people with
obesity and type 2 diabetes. We assessed the efficacy and safety of tirzepatide, a glucose …

[HTML][HTML] Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial

TA Wadden, AM Chao, S Machineni, R Kushner… - Nature Medicine, 2023 - nature.com
The effects of tirzepatide, a glucose-dependent insulinotropic polypeptide and glucagon-like
peptide-1 receptor agonist, on weight reduction after successful intensive lifestyle …

Efficacy and safety of the dual GIP and GLP-1 receptor agonist tirzepatide for weight loss: A meta-analysis of randomized controlled trials

YLL de Mesquita, I Pera Calvi, I Reis Marques… - International Journal of …, 2023 - nature.com
Objectives Tirzepatide is a dual glucose-dependent insulinotropic polypeptide and glucagon-
like peptide-1 receptor agonist approved for type 2 diabetes. We performed a meta-analysis …

Efficacy and tolerability of tirzepatide, a dual glucose‐dependent insulinotropic peptide and glucagon‐like peptide‐1 receptor agonist in patients with type 2 diabetes …

JP Frias, MA Nauck, J Van, C Benson… - Diabetes, Obesity …, 2020 - Wiley Online Library
Aim To assess the efficacy and tolerability of tirzepatide treatment using three different dose‐
escalation regimens in patients with type 2 diabetes. Materials and Methods In this double …

[HTML][HTML] Weight loss efficiency and safety of tirzepatide: A Systematic review

F Lin, B Yu, B Ling, G Lv, H Shang, X Zhao, X Jie… - Plos one, 2023 - journals.plos.org
Objective Tirzeptide is a novel glucagon-like peptide-1 receptor (GLP-1) and glucose-
dependent insulinotropic polypeptide (GIP) drug, which shows good efficiency for weight …

Tirzepatide for the treatment of adults with type 2 diabetes: an endocrine perspective

C De Block, C Bailey, C Wysham… - Diabetes, Obesity …, 2023 - Wiley Online Library
Tirzepatide is a novel glucose‐dependent insulinotropic polypeptide/glucagon‐like peptide
1 (GLP‐1) receptor agonist approved in the United States as an adjunct to diet and exercise …