Advantages and challenges of metagenomic sequencing for the diagnosis of pulmonary infectious diseases

Y Chen, LC Fan, YH Chai, JF Xu - The clinical respiratory …, 2022 - Wiley Online Library
Objective We aim to familiarize the application status of metagenomic sequencing in
diagnosing pulmonary infections, to compare metagenomic sequencing with traditional …

[HTML][HTML] Exploring the clinical utility of metagenomic next-generation sequencing in the diagnosis of pulmonary infection

G Xie, B Zhao, X Wang, L Bao, Y Xu, X Ren, J Ji… - Infectious diseases and …, 2021 - Springer
Introduction We aimed to explore the real-world clinical application value and challenges of
metagenomic next-generation sequencing (mNGS) for pulmonary infection diagnosis …

[HTML][HTML] Diagnostic performance of the metagenomic next-generation sequencing in lung biopsy tissues in patients suspected of having a local pulmonary infection

S Su, X Chen, L Zhou, P Lin, J Chen, C Chen… - BMC Pulmonary …, 2022 - Springer
Purpose This study aims to evaluate the diagnostic application and performance of the
metagenomic next-generation sequencing (mNGS) in patients suspected of local pulmonary …

[HTML][HTML] Detection of pulmonary infectious pathogens from lung biopsy tissues by metagenomic next-generation sequencing

H Li, H Gao, H Meng, Q Wang, S Li, H Chen… - Frontiers in cellular …, 2018 - frontiersin.org
Metagenomic next-generation sequencing (mNGS) is a comprehensive approach for
sequence-based identification of pathogenic microbes. However, reports on the use of …

[HTML][HTML] Improving pulmonary infection diagnosis with metagenomic next generation sequencing

YY Qian, HY Wang, Y Zhou, HC Zhang… - Frontiers in cellular …, 2021 - frontiersin.org
Pulmonary infections are among the most common and important infectious diseases due to
their high morbidity and mortality, especially in older and immunocompromised individuals …

Clinical application of metagenomic next‐generation sequencing technology in the diagnosis and treatment of pulmonary infection pathogens: A prospective single …

N Li, X Ma, J Zhou, J Deng, C Gu, C Fei… - Journal of clinical …, 2022 - Wiley Online Library
Introduction Rapid and accurate pathogen identification is essential for the treatment of
pneumonia. Metagenomic next‐generation sequencing (mNGS) is a newly developed …

The clinical application of metagenomic next-generation sequencing for detecting pathogens in bronchoalveolar lavage fluid: case reports and literature review

HF Tsang, ACS Yu, N Jin, AKY Yim… - Expert Review of …, 2022 - Taylor & Francis
Introduction Clinical metagenomic next-generation sequencing (mNGS) allows a
comprehensive genetic analysis of microbial materials. Different from other traditional target …

Metagenomic sequencing as a pathogen-agnostic clinical diagnostic tool for infectious diseases: a systematic review and meta-analysis of diagnostic test accuracy …

KN Govender, TL Street, ND Sanderson… - Journal of clinical …, 2021 - Am Soc Microbiol
Metagenomic sequencing is frequently claimed to have the potential to revolutionize
microbiology through rapid species identification and antimicrobial resistance (AMR) …

[HTML][HTML] Respiratory metagenomics: route to routine service

JD Edgeworth - Current Opinion in Infectious Diseases, 2023 - journals.lww.com
Pathogen sequencing is a transformational proposition for microbiology laboratories and
their infectious diseases, infection control, and public health partners. Healthcare systems …

Improving suspected pulmonary infection diagnosis by bronchoalveolar lavage fluid metagenomic next-generation sequencing: a multicenter retrospective study

X Jin, J Li, M Shao, X Lv, N Ji, Y Zhu… - Microbiology …, 2022 - Am Soc Microbiol
Metagenomic next-generation sequencing (mNGS) has been gradually applied to clinical
practice due to its unbiased characteristics of pathogen detection. However, its diagnostic …