Adenine base editors (ABEs) catalyze A-to-G transitions showing broad applications, but
their bystander mutations and off-target editing effects raise safety concerns. Through …

Adenine base editors (ABEs) catalyze specific A-to-G conversions at genomic sites of
interest. However, ABEs also induce cytosine deamination at the target site. To reduce the …

Base editing induces single-nucleotide changes in the DNA of living cells using a fusion
protein containing a catalytically defective Streptococcus pyogenes Cas9, a cytidine …

Adenine base editors (ABEs) are precise gene-editing agents that convert A: T pairs into G:
C through a deoxyinosine intermediate. Existing ABEs function most effectively when the …

Cytosine base editors (CBEs) offer a powerful tool for correcting point mutations, yet their
DNA and RNA off-target activities have caused concerns in biomedical applications. We …

Adenine base editors (ABEs) are novel genome-editing tools, and their activity has been
greatly enhanced by eight additional mutations, thus named ABE8e. However, elevated …

Base editors have substantial promise in basic research and as therapeutic agents for the
correction of pathogenic mutations. The development of adenine transversion editors has …

A recently developed adenine base editor (ABE) efficiently converts A to G and is potentially
useful for clinical applications. However, its precision and efficiency in vivo remains to be …

The adenine base editor (ABE), capable of catalyzing A• T to G• C conversions, is an
important gene editing toolbox. Here, we systematically evaluate genome-wide off-target …

The clustered regularly interspaced short palindromic repeat (CRISPR) system has been
widely adapted to genome editing to either introduce or correct genetic mutations (Wang et …