Environmental exposure to phthalates during intrauterine development might increase
susceptibility to neoplasms in reproductive organs such as the prostate. Although studies …

Endocrine disrupting chemicals (EDCs) in the environment are considered to be a
contributing factor to the decline in the sperm quality. With growing evidence of the harmful …

Phthalates represent a group of substances used in industry that have antiandrogenic
activity and are found in different concentrations in human urine and plasma. More than 8 …

Phthalate chemical plasticizers can damage the fetal and postnatal mammalian testis, but
several aspects of the injury mechanism remain unknown. Using a genome-wide …

Background Phthalate exposure induces germ cell effects in the fetal rat testis. Although
experimental models have shown that the human fetal testis is insensitive to the …

Background Endocrine-disrupting effects of phthalates are understood primarily from in
utero exposures within the fetal rat testis. Nevertheless, their path of action, dose–response …

Abstract di (2-ethylhexyl) phthalate (DEHP) is one of the most commonly-used plasticizers
and can exert estrogen-like effects and anti-androgen-like effects after entering the body …

Abstract Di (2-ethylhexyl) phthalate (DEHP) early exposure leads to immature testicular
injury, and we aimed to utilize single-cell RNA (scRNA) sequencing to comprehensively …

As an ubiquitous environmental endocrine disruptor, di (2-ethylhexyl) phthalate (DEHP) has
been shown to interfere with the development of reproductive organs and induce …

Preconception environmental conditions have been demonstrated to shape sperm
epigenetics and subsequently offspring health and development. Our previous findings in …